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Lack of association of human polyomaviruses with human brain tumors

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Summary

Brain tumors, primarily glioblastoma multiforme, were examined for the presence of BKV DNA. DNAs extracted from 33 fresh-frozen tumors and from an additional 47 paraffin-embedded tumor tissues were tested for BKV sequences using two different primer pairs. One primer pair amplified highly conserved sequences in the early region coding for BKV and JCV T antigens. The other primer pair amplified the regulatory region of BKV-IR, a variant previously associated with human brain tumors. None of the tumors were positive for BKV or JCV DNA.

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Authors and Affiliations

  1. Department of Immunology and Infectious Diseases, School of Hygiene and Public Health, Johns Hopkins University, USA

    Ray R. Arthur & Keerti V. Shah

  2. Johns Hopkins Oncology Center, USA

    Stuart A. Grossman, Sandra H. Bigner & Bert Vogelstein

  3. Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA

    Brigitte M. Ronnett

Authors
  1. Ray R. Arthur
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  2. Stuart A. Grossman
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  3. Brigitte M. Ronnett
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  4. Sandra H. Bigner
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  5. Bert Vogelstein
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  6. Keerti V. Shah
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Arthur, R.R., Grossman, S.A., Ronnett, B.M. et al. Lack of association of human polyomaviruses with human brain tumors. J Neuro-Oncol 20, 55–58 (1994). https://doi.org/10.1007/BF01057961

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