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The Pathobiology of Polyomavirus Infection in Man

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Polyomaviruses and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 577))

Abstract

This article traces the discovery of polyomaviruses and outlines investigations, which shed light on potential modes of transmission of this increasingly important group of human pathogens. The pathobiology of the virus is summarized with particular reference to interactions with host cell receptors, cell entry, cytoplasmic trafficking, and targeting of the viral genome to the nucleus. This is followed by a discussion of sites of viral latency and factors leading to viral reactivation. Finally, we present biochemical mechanisms that could potentially explain several key elements of tissue pathology characteristic of BKV mediated damage to human kidney.

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Authors and Affiliations

  1. University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

    Parmjeet Randhawa M.D. & Ron Shapiro M.D.

  2. Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Abhay Vats M.D.

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  1. Parmjeet Randhawa M.D.
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  2. Abhay Vats M.D.
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  3. Ron Shapiro M.D.
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  1. Mayo Clinic Transplant Center, Mayo Clinic - College of Medicine, Jacksonville, Florida, USA

    Nasimul Ahsan M.D., FACP

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Randhawa, P., Vats, A., Shapiro, R. (2006). The Pathobiology of Polyomavirus Infection in Man. In: Ahsan, N. (eds) Polyomaviruses and Human Diseases. Advances in Experimental Medicine and Biology, vol 577. Springer, New York, NY. https://doi.org/10.1007/0-387-32957-9_10

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