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Curved DNA and Prokaryotic Promoters

A Mechanism for Activation of Transcription

  • Chapter
DNA Conformation and Transcription

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

Abstract

Intrinsically curved DNA structures often occur in or around origins of DNA replication, regions that regulate transcription, and DNA recombination loci, and are found in a wide variety of cellular and viral genomes from bacteria to man. In bacterial promoters, bent DNA structures are often located from immediately upstream of the −35 hexamer to around position −100 relative to the transcription start site (+1). They have a range of functions: facilitating RNA polymerase binding to the promoter, transition from closed to open promoter complexes, or transcription factor binding. To perform these functions, in some cases intrinsically curved structures function together with DNA bends that are induced by binding of RNA polymerase, transcription factors, or nucleoid-associated proteins. This chapter will describe how curved DNA structures are implicated in prokaryotic transcription.

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  1. Laboratory of Molecular Genetics School of Agriculture, Ibaraki University, Ibaraki, Japan

    Munehiko Asayama

  2. Department of Biology Faculty of Science and Engineering, Konan University, Kobe, Japan

    Takashi Ohyama

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Asayama, M., Ohyama, T. (2005). Curved DNA and Prokaryotic Promoters. In: DNA Conformation and Transcription. Molecular Biology Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/0-387-29148-2_3

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