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Oxidimetric Titration of Some Phenothiazine Neuroleptics and Antiallergics with Potassium Dichromate

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Abstract

Three simple, rapid and accurate titrimetric procedures using potassium dichromate as titrant are described for the determination of six phenothiazine drugs in a pure form and in dosage forms. The procedures are based on the oxidation of phenothiazines in an acid medium to colorless sulfoxides via orange- or purple-colored intermediates. In the first method, phenothiazines are titrated directly in a H2SO4 medium to a colorless end-point. In the second procedure, a known excess of oxidant is added, and after a specified time the residual oxidant is determined iodometrically. The third method employs potentiometric end-point detection. The optimum reaction conditions and other analytical parameters are evaluated and the molar-ratio of the reaction is also calculated. The influence of the substrates commonly employed as excipients with phenothiazine drugs has been studied. A statistical comparison of the results obtained for pure drugs with those of an official method shows excellent agreement and indicates no significant difference in precision.

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References

  1. M. Gordon (ed.), “Psychopharmacological Agents”, Vol. II, Academic Press, New York, 1964.

  2. A. N. Nayak, Rangaswamy, H. S. Yathirajan and P. G. Ramappa, Indian Drugs, 19, 202 (1982).

    Google Scholar 

  3. A. S. Issa and M. S. Mahrous, Talanta, 31, 287 (1984).

    Article  CAS  Google Scholar 

  4. V. N. Pathak, I. C. Shukla and S. R. Shukla, Talanta, 29, 58 (1982).

    Article  CAS  Google Scholar 

  5. M. I. Walash, M. Rizk, A. Abdel-Malik and F. Belal, Analyst [London], 108, 626 (1983).

    Article  CAS  Google Scholar 

  6. M. I. Walash, F. Belal and F. A. Aly, Talanta, 35, 320 (1988).

    Article  CAS  Google Scholar 

  7. M. Stan, F. Dima and G. Ghimicescu, Rev. Med-chir., 82, 337 (1978).

    CAS  Google Scholar 

  8. J. Milne, J. Pharm. Assoc., 48, 117 (1959).

    Article  CAS  Google Scholar 

  9. A. Olech, Acta Pol. Pharm., 30, 505 (1973).

    CAS  PubMed  Google Scholar 

  10. U. M. Abbasi, M. Siddiqui and M. I. Bhangas, J. Chem. Soc. Pak, 13, 242 (1991).

    CAS  Google Scholar 

  11. W. Misiuik and M. Tarasiewicz, Pharmazie, 51, 62 (1996).

    Google Scholar 

  12. V. P. Kalashnikov, A. I. Shkadova and T. G. Popova, Farm. Zh. [Kiev], 5–6, 68(1992); [Anal. Abstr., 55, 9G153 (1993) ].

    Google Scholar 

  13. L. Kuzmicka, L. Puzanowska-Tarasiewicz and M. Tarasiewicz, Pharmazie, 43, 288 (1988).

    CAS  Google Scholar 

  14. M. M. El-Kerdway, S. M. Hassan and S. M. El-Ashry, Mikrochim. Acta, 108, 323(1992).

    Article  Google Scholar 

  15. H. Puzanowska-Tarasiewicz and J. Karpinska, Pharmazie, 44, 350 (1989).

    CAS  Google Scholar 

  16. F. A. Mohamed, Anal. Lett, 28, 2491 (1995).

    Article  CAS  Google Scholar 

  17. D. De Orsi, L. Gagliardi and D. Tonelli, J. Pharm. Biomed. Anal, 14, 1635 (1996).

    Article  Google Scholar 

  18. X. Y. Hu and Z. Z. Leng, YaouxeXuebao, 27, 283 (1992).

    CAS  Google Scholar 

  19. T. Peng, R. Yang and R. Lu, Zhongguo Yaouxe Zazhi, 25, 277 (1990).

    CAS  Google Scholar 

  20. S. R. El-Shabouri, A. F. Yossef and F. A. Mohammed, J. Assoc. Off. Anal. Chem, 69, 821 (1986).

    CAS  PubMed  Google Scholar 

  21. M. S. Mahrous and M. M. Abdel Khalek, Talanta, 31, 289 (1984).

    Article  CAS  Google Scholar 

  22. S. M. Sultan, Talanta, 34, 605 (1987).

    Article  CAS  Google Scholar 

  23. C. S. P. Sastry, M. Aruna and A. R. M. Rao, Talanta, 35, 23 (1988).

    Article  CAS  Google Scholar 

  24. S. M. Sultan, Talanta, 40, 681 (1993).

    Article  CAS  Google Scholar 

  25. G. Dusinsky and O. Liskova, Chem. Zvesti, 12, 213 (1958).

    CAS  Google Scholar 

  26. W. G. Belikov and G. F. Moiseeva, Farmatsiya[Moscow], 36, 87 (1986).

    Google Scholar 

  27. C. C. Gowda and S. M. Mayanna, Indian Drugs, 31, 574 (1994).

    Google Scholar 

  28. “British Pharmacopoeia 1993”, Her Majesty’s Stationery Office, London, 1993, pp. 832, 833, 1073, 1076, 1079, 1140.

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Authors and Affiliations

  1. Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore-, 570 006, India

    K. Basavaiah

  2. Department of Chemistry, PES College of Science, Mandya-, 571 401, India

    G. Krishnamurthy

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  1. K. Basavaiah
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  2. G. Krishnamurthy
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Basavaiah, K., Krishnamurthy, G. Oxidimetric Titration of Some Phenothiazine Neuroleptics and Antiallergics with Potassium Dichromate. ANAL. SCI. 15, 67–71 (1999). https://doi.org/10.2116/analsci.15.67

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  • DOI: https://doi.org/10.2116/analsci.15.67

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