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Electrochemical characterization of SnO2/rGO nanostructure for selective quantification of captopril in real matrix

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Abstract

Captopril (CAP) is one of the most broadly consumed anti-hypertension drug that caused various harmful effects such as zinc deficiency, cough, agranulocytosis, and angioedema. Thus, monitoring the low-level concentration of CAP through reliable and sensitive method is of great significance. The electrocatalytic properties of newly fabricated sensor based on SnO2/rGO/PtE was evaluated through Tafel plot and electrochemical impedance spectroscopy. The engineered sensor exhibited excellent response for CAP under optimal conditions e.g., PBS electrolyte (pH 5), scan sweep 90 mV/s and potential window (0.6 to 1.9 V). For effectiveness of developed sensor, two low and high concentration ranges of CAP were optimized as 1 to 700 nM and 10 100 µM, respectively. The LOD’s of SnO2/rGO/PtE for CAP for low and high concentrations were calculated as 0.061 nM and 0.0018 µM. Moreover, the exceptional long-term stability and anti-interference profile of SnO2/rGO/PtE suggested the reliability of chemically modified sensor.

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Acknowledgments

We are highly thankful to HEC Pakistan for providing us the fund to carry out this research under the program (HEC Indigenous 5000 scholarship phase-II batch-VI)

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Authors and Affiliations

  1. National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan

    Jamil A. Buledi, Amber R. Solangi, Saba Ali & Tania Ghumro

  2. M.A. Kazi Institute of Chemistry, University of Sindh, Jamshoro, 76080, Sindh, Pakistan

    Arfana Malah, Saima Q. Memon & Nasrullah Mahar

  3. Department of Chemistry, King Fahad University of Petroleum and Minerals (KFUPM), Dhahran, Saudi Arabia

    Nasrullah Mahar

  4. Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey

    Ismail M. Palabiyik

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  1. Jamil A. Buledi
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Buledi, J.A., Solangi, A.R., Malah, A. et al. Electrochemical characterization of SnO2/rGO nanostructure for selective quantification of captopril in real matrix. Journal of Materials Research 38, 2764–2774 (2023). https://doi.org/10.1557/s43578-023-01000-1

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