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Silymarin-loaded electrospun polycaprolactone nanofibers as wound dressing

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Abstract

Herein, we fabricated silymarin (SIL)-loaded polycaprolactone (PCL) electrospun nanofiber mats containing different SIL concentrations (5, 7.5, 10%) for wound dressing applications. Solution properties, nanofiber properties and SIL presence were analyzed by viscosity measurements, SEM and FTIR, respectively. Solution viscosities were increased with increasing SIL concentrations resulting in bead-free, thicker and smooth nanofibers. The lowest contact angle was measured as ~ 92° for 10% SIL-loaded sample which had the smoothest nanofibers and a more controlled and continuous SIL release with a rate of 68.29% at end of 144 h during in vitro release experiments. In vivo studies on rats were conducted on this sample and results were compared with a conventional wound dressing and a PCL nanofiber mat. In comparison, the 10% SIL-loaded sample provided more rapid and significantly greater wound healing from the first day of observation. The results confirmed the potential application of PCL/SIL electrospun nanofiber mats as wound dressing.

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Acknowledgments

Authors would like to thank Erkan Ermis for his technical assistance during the in vivo studies and Sema Isik for her technical support during the in vitro studies. This study is a part of Aisegkioul Sali’s MSc thesis and was financially supported by The Scientific Research Commission of Bursa Uludag University with the project number of THIZ-2021-680.

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  1. Department of Biomaterials, Bursa Uludag University Graduate School of Natural and Applied Science, Bursa, Turkey

    Aisegkioul Sali & Gokhan Goktalay

  2. Department of Textile Engineering, Faculty of Engineering, Bursa Uludag University, Bursa, Turkey

    Sebnem Duzyer Gebizli

  3. Department of Pharmacology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkey

    Gokhan Goktalay

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  1. Aisegkioul Sali
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Sali, A., Duzyer Gebizli, S. & Goktalay, G. Silymarin-loaded electrospun polycaprolactone nanofibers as wound dressing. Journal of Materials Research 38, 2251–2263 (2023). https://doi.org/10.1557/s43578-023-00959-1

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