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Volumetric bioprinting strategies for creating large-scale tissues and organs

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Abstract

Engineered tissues and organs that approximate the sizes and functions of actual organs hold great promise for advancing medicine and pharmacology. However, significant challenges remain in producing clinically relevant biofabricated constructs using traditional tissue-engineering techniques. The use of three-dimensional volumetric bioprinting technology is expected to enable the creation of large-scale functional organs for various applications. In this article, we discuss key considerations for creating volumetric functional tissue constructs, particularly using bioprinting technology. In addition, we critically evaluate the advantages and limitations of current volumetric bioprinting techniques, and highlight recent advances in volumetric bioprinting applications that can address the donor organ shortage and the lack of reliable in vitro models.

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Acknowledgments

This research was supported by the Korean Fund for Regenerative Medicine (21A0104L1, Republic of Korea) funded by the Ministry of Science and ICT, Ministry of Health and Welfare, and the Alchemist Project (20012378, Republic of Korea) funded by the Ministry of Trade, Industry & Energy.

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  1. Daekeun Kim and Dayoon Kang have contributed equally to this work.

Authors and Affiliations

  1. Center for 3D Organ Printing and Stem Cells, Pohang University of Science and Technology, Pohang, Republic of Korea

    Daekeun Kim, Dayoon Kang, Donghwan Kim & Jinah Jang

  2. Department of Convergence IT Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Daekeun Kim & Jinah Jang

  3. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Donghwan Kim & Jinah Jang

  4. Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea

    Jinah Jang

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  1. Daekeun Kim
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Kim, D., Kang, D., Kim, D. et al. Volumetric bioprinting strategies for creating large-scale tissues and organs. MRS Bulletin 48, 657–667 (2023). https://doi.org/10.1557/s43577-023-00541-4

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