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Allergen avoidance as primary prevention

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Abstract

There has been a dramatic increase in the prevalence of atopic diseases, such as atopic dermatitis, food allergy, allergic rhinitis, and allergic asthma. Because environmental factors such as early allergen exposure to nutritional and inhalant allergens have been suspected as potential environmental factors favoring the development of allergic diseases and asthma, primary prevention studies have begun to investigate the effect on sensitization and wheezing. Designs of the studies are different and, therefore, are not completely comparable. Although no clear primary prevention study is available for pets, mite allergen avoidance during infancy can achieve a reduction of specific sensitization and, in some studies, can also produce a slight effect on respiratory symptoms.

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References

  1. Sears, M.R. (1997), Lancet 350, 1015–1020.

    Article  PubMed  CAS  Google Scholar 

  2. Aberg, N., Hesselmar, B., Aberg, B., et al. (1995), Clin Exp Allergy 25, 815–819.

    Article  PubMed  CAS  Google Scholar 

  3. Wahn, U. and von Mutius, E. (2001), J Allergy Clin Immunol 107, 567–574.

    Article  PubMed  CAS  Google Scholar 

  4. Lau, S., Illi, S., Sommerfeld, C., et al. (2000), Lancet 356, 1392–1397.

    Article  PubMed  CAS  Google Scholar 

  5. Eder, W. and von Mutius, E. (2004), Curr Opin Allergy Clin Immunol 4, 113–117.

    Article  PubMed  CAS  Google Scholar 

  6. Peat, J., van den Berg, R.H., Green, W.F., et al. (1994), BMJ 308, 1591–1596.

    PubMed  CAS  Google Scholar 

  7. Sears, M.R., Herbison, G.P., Holdaway, M.D., et al. (1989), Clin Exp Allergy 19, 419–424.

    Article  PubMed  CAS  Google Scholar 

  8. Kuehr, J., Frischer, T., Meinert, R., et al. (1994), J Allergy and Clin Immunol 95, 655–662.

    Article  Google Scholar 

  9. Peat, J.K. and Li, J. (1999), J Allergy Clin Immunol 103, 1–10.

    Article  PubMed  CAS  Google Scholar 

  10. Williams, H., Robertson, C., Stewart, A., et al. (1999), J Allergy Clin Immunol 103, 125–138.

    Article  PubMed  CAS  Google Scholar 

  11. Sporik, R., Ingram, J.M., Price, W., et al. (1997), Am J Respir Crit Care Med 155, 1356–1361.

    Google Scholar 

  12. Kuehr, J., Frischer, T., Meinert, R., et al. (1994), J Allergy Clin Immunol 94, 44–52.

    Article  PubMed  CAS  Google Scholar 

  13. Wahn, U., Lau, S., Bergmann, R., et al. (1997), J Allergy Clin Immunol 99, 763–769.

    Article  PubMed  CAS  Google Scholar 

  14. Ehnert, B., Lau-Schadendorf, S., Weber, A., et al. (1992), J Allergy Clin Immunol 90, 135–138.

    PubMed  CAS  Google Scholar 

  15. Platts-Mills, T.A.E., Tovey, E.R., Mitchell, E.R., et al. (1982), Lancet 2, 675–678.

    Article  PubMed  CAS  Google Scholar 

  16. Hide, D.W. (1997) Pediatr Pulmonol Suppl 16, 15–16.

    PubMed  CAS  Google Scholar 

  17. Gore, C. and Custovic, A. (2003), Paediatr Respir Rev 4(3), 213–224.

    Article  PubMed  Google Scholar 

  18. Becker, A.B. and Chan-Yeung, M. (2002), Curr Opin Pulm Med 8(1), 16–24.

    Article  PubMed  Google Scholar 

  19. Arshad, S. H., Matthews, S., Gant, C., and Hide, D.W. (1992), Lancet 339, 1493–1497.

    Article  PubMed  CAS  Google Scholar 

  20. Hide, D.W., Matthews, S., Matthews, L., et al. (1994), J Allergy Clin Immunol 93, 842–846.

    Article  PubMed  CAS  Google Scholar 

  21. Hide, D.W., Matthews, S., Tariq, S., et al. (1996), Allergy 51, 89–93.

    Article  PubMed  CAS  Google Scholar 

  22. Arshad, S.H., Bateman, B., and Matthews, S.M. (2003), Thorax 58(6), 489–493.

    Article  PubMed  CAS  Google Scholar 

  23. Chan-Yeung, M., Manfreda, J., Dimich-Ward, H., Ferguson, A., Watson, W., and Becker, A. (2000), Arch Pediatr Adolesc Med 154, 657–663.

    PubMed  CAS  Google Scholar 

  24. Custovic, A., Simpson, B., Simpson, A., et al. (2000), J Allergy Clin Immunol 105, 252–258.

    Article  PubMed  CAS  Google Scholar 

  25. Custovic, A., Simpson, B.M., Simpson, A., Kissen, P., and Woodcock, A. (2001), Lancet 358, 188–193.

    Article  PubMed  CAS  Google Scholar 

  26. Simpson, A., Simpson, B., Custovic, A., Craven, M., and Woodcock, A. (2003), Clin Exp Allergy 33, 1183–1189.

    Article  PubMed  CAS  Google Scholar 

  27. Arshad, S.H., Bojarskas, J., Tsitoura, S., et al. (2002), Clin Exp Allergy 32, 843–849.

    Article  PubMed  CAS  Google Scholar 

  28. Halmerbauer, G., Gartner, C., Schierl, M., et al. (2003), Pediatr Allergy Immunol 14, 10–17.

    Article  PubMed  Google Scholar 

  29. Mihrshahi, S., Peat, J., Webb, K., et al. (2001), Control Clin Trials 22, 333–354.

    Article  PubMed  CAS  Google Scholar 

  30. Mihrshahi, S., Marks, G.B., Criss, S., et al. (2003), Allergy 58, 784–789.

    Article  PubMed  CAS  Google Scholar 

  31. Mihrshahi, S., Peat, J., Marks, G.B., et al. (2003), J Allergy Clin Immunol 111, 162–168.

    Article  PubMed  CAS  Google Scholar 

  32. Brunekreef, B., Smit, J., de Jongste, J., et al. (2002), Pediatr Allergy Immunol 13, 55–60.

    Article  PubMed  Google Scholar 

  33. Koopman, L.P., van Strien, R.T., Kerkhof, M., et al. (2002), Am J Respir Crit Care Med 166, 307–313.

    Article  PubMed  Google Scholar 

  34. Van Strien, R.T., Koopman, L.P., Kerkhof, M., et al. (2003), Clin Exp Allergy 33, 490–495.

    Article  PubMed  Google Scholar 

  35. Von Berg, A., Koletzko, S., Gruebl, A., et al. (2003), J Allergy Clin Immunol 11, 467–470.

    Google Scholar 

  36. Ownby, P.R., Johnson, C.C., and Peterson, E.L. (2002), JAMA 288, 963–972.

    Article  PubMed  Google Scholar 

  37. Almqvist, C., Egmar, A.-C., van Hage-Hamsten, M., et al. (2003), J Allergy Clin Immunol 111, 800–806.

    Article  PubMed  Google Scholar 

  38. Anyo, G., Brunekreef, B., de Meer, G., Aarts, F., Jansson, N., and van Vliet, P. (2002), Clin Exp Allergy 32, 361–366.

    Article  PubMed  CAS  Google Scholar 

  39. Nafstad, P., Magnus, P., Gaarder, P.I., and Jaakkola, J.J.K. (2001), Allergy 56, 307–312.

    Article  PubMed  CAS  Google Scholar 

  40. Hesselmar, B., Aberg, N., Aberg, B., Eriksson, B., and Bjöksten, B. (1999), Clin Exp Allergy 29, 611–617.

    Article  PubMed  CAS  Google Scholar 

  41. Apelberg, B.J., Aoki, Y., and Jaakkola, J.J.K. (2001), J Allergy Clin Immunol 107, 455–460.

    Article  PubMed  CAS  Google Scholar 

  42. Perzanowski, M.S., Ronmark, E., Platts-Mills, T.A.E., and Lundback, B. (2002), Am J Respir Crit Care Med 166, 696–702.

    Article  PubMed  Google Scholar 

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Lau, S. Allergen avoidance as primary prevention. Clinic Rev Allerg Immunol 28, 17–23 (2005). https://doi.org/10.1385/CRIAI:28:1:017

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