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Influences of the Charlson Comorbidity Index and Nutrition Status on Prognosis After Esophageal Cancer Surgery

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The Charlson Comorbidity Index (CCI), an indicator that objectively quantifies comorbidities, reduces nutritional status; however, the impact of the CCI on the postoperative nutrition indexes of patients with esophageal cancer remains unclear.

Methods

In total, 336 patients with esophageal cancer who underwent surgery between January 2011 and April 2017 were included in this study. We investigated the relationship between the CCI and postoperative nutrition indexes.

Results

Patients were divided into two groups: CCI ≤1 (low CCI group) and CCI ≥2 (high CCI group). A high CCI was significantly associated with shortened overall survival (OS; 3-year OS rate of 77.9% in the low CCI group versus 59.7% in the high CCI group; p = 0.008). Nutritional indexes, such as the Prognostic Nutritional Index (PNI), at 1 month after esophagectomy were significantly lower in the high CCI group than in the low CCI group (p = 0.031); however, the PNI at 6 months after surgery was similar between the high and low CCI groups. Multivariate analysis identified high CCI as an independent risk factor associated with PNI <45 in esophageal cancer patients at 1 month after esophagectomy (p = 0.047).

Conclusion

This study showed that CCI ≥2 was significantly associated with poor PNI at 1 month after surgery for esophageal cancer, indicating that it is necessary to administer effective nutritional interventions for patients with postoperative malnutrition, especially those with multiple comorbidities.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan

    Yuto Kubo MD, Koji Tanaka MD, PhD, Makoto Yamasaki MD, PhD, Kotaro Yamashita MD, PhD, Tomoki Makino MD, PhD, Takuro Saito MD, PhD, Kazuyoshi Yamamoto MD, PhD, Tsuyoshi Takahashi MD, PhD, Yukinori Kurokawa MD, PhD, Masaaki Motoori MD, PhD, Kiyokazu Nakajima MD, PhD, Hidetoshi Eguchi MD, PhD & Yuichiro Doki MD, PhD

  2. Department of Surgery, Faculty of Medicine, Kindai University, Osaka-Sayama, Japan

    Yutaka Kimura MD, PhD

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  1. Yuto Kubo MD
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Correspondence to Koji Tanaka MD, PhD.

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Disclosure

Yuto Kubo, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Tomoki Makino, Takuro Saito, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Masaaki Motoori, Yutaka Kimura, Kiyokazu Nakajima, Hidetoshi Eguchi, and Yuichiro Doki have no conflicts of interest to declare.

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Kubo, Y., Tanaka, K., Yamasaki, M. et al. Influences of the Charlson Comorbidity Index and Nutrition Status on Prognosis After Esophageal Cancer Surgery. Ann Surg Oncol 28, 7173–7182 (2021). https://doi.org/10.1245/s10434-021-09779-1

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  • DOI: https://doi.org/10.1245/s10434-021-09779-1

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