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Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential Application as Injectable Drug Delivery System

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Abstract

Thermosensitive hydrogels are of great interest for in situ gelling drug delivery. The thermosensitive vehicle with a gelation temperature in a range of 30–36°C would be convenient to be injected as liquid and transform into gel after injection. To prepare novel hydrogels gelling near body temperature, the gelation temperature of poloxamer 407 (PX) were tailored by mixing PX with poly(acrylic acid) (PAA). The gelation behaviors of PX/PAA systems as well as the interaction mechanism were investigated by tube inversion, viscoelastic, shear viscosity, DSC, SEM, and FTIR studies. The gelation temperature of the plain PX solutions at high concentration of 18, 20, and 22% (w/w) gelled at temperature below 28°C, which is out of the suitable temperature range. Mixing PX with PAA to obtain 18 and 20% (w/w) PX with 1% (w/w) PAA increased the gelation temperature to the desired temperature range of 30–36°C. The intermolecular entanglements and hydrogen bonds between PX and PAA may be responsible for the modulation of the gelation features of PX. The mixtures behaved low viscosity liquid at room temperature with shear thinning behavior enabling their injectability and rapidly gelled at body temperature. The gel strength increased, while the pore size decreased with increasing PX concentration. Metronidazole, an antibiotic used for periodontitis, was incorporated into the matrices, and the drug did not hinder their gelling ability. The gels showed the sustained drug release characteristic. The thermosensitive PX/PAA hydrogel could be a promising injectable in situ gelling system for periodontal drug delivery.

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Acknowledgements

This work was financially supported by Walailak University through Grant Number WU60309. The authors also acknowledge the support of the Health Science Research Center and the Center for Scientific and Technological Equipments, Walailak University, for research facilities.

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Authors and Affiliations

  1. School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80161, Thailand

    Wannisa Boonlai, Namon Hirun & Tanatchaporn Sangfai

  2. Center of Excellence for Drug Delivery System and Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, 90112, Thailand

    Vimon Tantishaiyakul & Krit Suknuntha

  3. Drug and Cosmetics Excellence Center, Walailak University, Nakhon Si Thammarat, 80161, Thailand

    Namon Hirun

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  1. Wannisa Boonlai
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Correspondence to Namon Hirun.

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Boonlai, W., Tantishaiyakul, V., Hirun, N. et al. Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential Application as Injectable Drug Delivery System. AAPS PharmSciTech 19, 2103–2117 (2018). https://doi.org/10.1208/s12249-018-1010-7

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