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Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease

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Abstract

One of the main factors associated with worse prognosis in oncology is metastasis, which is based on the ability of tumor cells to migrate from the primary source and to form secondary tumors. The search for new strategies to control migration of metastatic cells is one of the urgent issues in biomedicine. One of the strategies to stop spread of cancer cells could be regulation of the nuclear elasticity. Nucleus, as the biggest and stiffest cellular compartment, determines mechanical properties of the cell as a whole, and, hence, could prevent cell migration through the three-dimensional extracellular matrix. Nuclear rigidity is maintained by the nuclear lamina, two-dimensional network of intermediate filaments in the inner nuclear membrane (INM). Here we present the most significant factors defining nucleus rigidity, discuss the role of nuclear envelope composition in the cell migration, as well consider possible approaches to control lamina composition in order to change plasticity of the cell nucleus and ability of the tumor cells to metastasize.

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Abbreviations

ER:

endoplasmic reticulum

HGPS:

Hutchinson–Guildford Progeria

LBR:

Lamin B receptor

nt:

nucleotide

ZMPSTE24:

zinc metallopeptidase STE24

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Acknowledgments

The authors express their gratitude to E. D. Ryumina for her technical help in preparation of the text.

Funding

This work was financially supported by the Russian Foundation for Basic Research (project no. 19-315-90069) and by the Russian Science Foundation (project no. 17-15-01290).

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Authors and Affiliations

  1. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992, Moscow, Russia

    Natalia L. Ovsiannikova, Svetlana V. Lavrushkina, Oxana A. Zhironkina & Igor I. Kireev

  2. Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119234, Moscow, Russia

    Natalia L. Ovsiannikova & Svetlana V. Lavrushkina

  3. Faculty of Biology, Lomonosov Moscow State University, 119234, Moscow, Russia

    Anastasia V. Ivanova, Ludmila M. Mazina & Igor I. Kireev

  4. Kulakov National Medical Research Center for Obstetrics, Gynecology, and Perinatology, 117198, Moscow, Russia

    Igor I. Kireev

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Ovsiannikova, N.L., Lavrushkina, S.V., Ivanova, A.V. et al. Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease. Biochemistry Moscow 86, 1288–1300 (2021). https://doi.org/10.1134/S0006297921100102

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