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Activation of Endogenous Mesenchymal Stromal Cells as an Approach to Tissue Regeneration

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Abstract

Mesenchymal stromal cells (MSCs), which have a complex proregenerative effect on damaged tissues, are a promising resource for cell therapy for a wide range of diseases. However, transplantation of autologous or donor MSCs to a patient is associated with a number of problems, such as variability in cell properties depending on the source and cultivation conditions, a decrease in their therapeutic potential, and the likelihood of acquiring immunogenicity or tumorigenicity during expansion in vitro, as well as the invasiveness of the extraction procedure. One way to avoid these problems may be by having an effect on endogenous MSCs by stimulating their directed migration into tissue defects without the need for extraction from the body, reproduction in vitro, and reintroduction to the patient. This review considers approaches to activating the mobilization of MSCs from tissue niches and/or stimulating their migration to the target area, which can be considered as a safer and possibly more effective alternative to MSC transplantation.

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The work was carried out at the expense of the budgetary funds of Sechenov First Moscow State University, Ministry of Health of the Russian Federation.

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  1. Sechenov First Moscow State University, Ministry of Health of Russia, 119991, Moscow, Russia

    O. V. Payushina, D. A. Tsomartova, E. V. Chereshneva, M. Yu. Ivanova, T. A. Lomanovskaya, M. S. Pavlova & S. L. Kuznetsov

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  1. O. V. Payushina
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  2. D. A. Tsomartova
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  3. E. V. Chereshneva
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Abbreviations. CSF—colony stimulating factor; G-CSF and GM-CSF—granulocytic and granulocyte-macrophage CSF, respectively.

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Payushina, O.V., Tsomartova, D.A., Chereshneva, E.V. et al. Activation of Endogenous Mesenchymal Stromal Cells as an Approach to Tissue Regeneration. Cell Tiss. Biol. 17, 328–338 (2023). https://doi.org/10.1134/S1990519X23040065

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