Skip to main content
SpringerLink
Log in

Neuroreceptor Profile and Behavior of CD-1 Mice Subpopulations with Different Attention Stability

  • EXPERIMENTAL ARTICLES
  • Published:
Neurochemical Journal Aims and scope Submit manuscript

Abstract—We used the radioligand binding method to study the neuroreceptor profile in the brain structures of subpopulations of outbred CD-1 mice that differ in stability of attention to environmental objects in the enriched closed plus maze test. In the prefrontal cortex of the subpopulation of mice with low attention to new objects, the density (Bmax, fmol/mg of protein) of D2-dopamine receptors was 25% higher whereas the density of GABAB-receptors was 34% lower compared to the mice with normal attention. We did not find any significant differences in the Kd and Bmax indices in the binding with NMDA-receptors in the hippocampus and prefrontal cortex between the subpopulations of mice. We additionally examined mouse behavior in the enriched closed plus maze and elevated plus maze tests using correlation and factor analysis. The index of attention to objects of the enriched closed plus maze correlated and had significant factor load with the indices of exploratory activity, such as time in center and amount of rearing in the elevated plus maze but did not correlate with anxiety indices.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.

Similar content being viewed by others

REFERENCES

  1. Faraone, S.V., Biederman, J., Weber, W., and Russell, R.L., J. Am. Acad. Child. Adolesc. Psychiatry, 1998, vol. 37, no. 2, pp. 185–193.

    Article  CAS  Google Scholar 

  2. Banaschewski, T., Becker, K., Scherag, S., Franke, B., and Coghill, D., Eur. Child. Adolesc. Psychiatry, 2010, vol. 19, no. 3, pp. 237–57.

    Article  Google Scholar 

  3. Cortese, S., Eur. J. Paediatr. Neurol., 2012, vol. 16, no. 5, pp. 422–433.

    Article  Google Scholar 

  4. Barker, R., Barazi, S., and Nil, M., Naglyadnaya nevrologiya (Neurology at a Glance), Ed. Skvortsova V.I., Moscow: GEOTAR-Media, 2006.

    Google Scholar 

  5. Davids, E., Zhang, K., Tarazi, F.I., and Baldessarini, R.J., Brain Res. Brain Res. Rev., 2003, vol. 42, no. 1, pp. 1–21.

    Article  Google Scholar 

  6. Salimov, R.M. and Kovalev, G.I., J. Behav. Brain Sci., 2012, vol. 2, no. 4, pp. 479–484.

    Article  Google Scholar 

  7. Salimov, R.M. and Kovalev, G.I., J. Behav. Brain Sci., 2013, vol. 3, no. 2, pp. 210–216.

    Article  Google Scholar 

  8. Aujnarain, A.B., Luo, O.D., Taylor, N., Lai, J.K.Y., and Foster, J.A., Behav. Brain Res., 2018, vol. 16, no. 342, pp. 43–50.

    Article  Google Scholar 

  9. Kovalev, G.I., Vasil’eva, E.V., and Salimov, R.M., Zhurn. Vyssh. Nervn. Deyat.im.I.P. Pavlova, 2019, vol. 69, no. 1, pp. 123–130.

    Google Scholar 

  10. Pellow, S., Chopin, P., File, S.E., and Briley, M., J. Neurosci. Methods, 1985, vol. 14, no. 3, pp. 149–167.

    Article  CAS  Google Scholar 

  11. Zhou, L.M., Gu, Z.Q., Costa, A.M., Yamada, K.A., and Manssone, P.E., J. Pharmacol. Exp. Ther., 1997, vol. 280, no. 1, pp. 422–427.

    CAS  PubMed  Google Scholar 

  12. LaPage, K.T., Ishmael, J.E., Low, C.W., Traynelis, S.F., and Murray, T.F., Neuropharmacology, 2005, vol. 49, pp. 1–16.

    Article  Google Scholar 

  13. Imafuku, J., Brain Res., 1987, vol. 402, no. 2, pp. 331–338.

    Article  CAS  Google Scholar 

  14. Bowery, N.G., Hill, D.R., and Hudson, A.L., Neuropharmacology, 1985, vol. 24, no. 3, pp. 207–210.

    Article  CAS  Google Scholar 

  15. Szekely, A.M., Barbaccia, M.L., and Costa, E., J. Pharmacol. Exp. Ther., 1987, vol. 243, no. 1, pp. 155–159.

    CAS  PubMed  Google Scholar 

  16. Kollins, S.H., Curr. Med. Res. Opin., 2008, vol. 24, no. 5, pp. 1345–1357.

    Article  Google Scholar 

  17. Madras, B.K., Miller, G.M., and Fischman, A.J., Biol. Psychiatry, 2005, vol. 57, no. 11, pp. 1397–1409.

    Article  CAS  Google Scholar 

  18. Ilgin, N., Senol, S., Gucuyener, K., Gokcora, N., and Sener, S., Dev. Med. Child. Neurol., 2001, vol. 43, no. 11, pp. 755–760.

    Article  CAS  Google Scholar 

  19. Montgomery, A.J., Asselin, M.C., Farde, L., and Grasby, P.M., J. Cereb. Blood Flow Metab., 2007, vol. 27, no. 2, pp. 369–377.

    Article  CAS  Google Scholar 

  20. Pezze, M., McGarrity, S., Mason, R., Fone, K.C., and Bast, T., J. Neurosci., 2014, vol. 34, pp. 7931–7946.

    Article  CAS  Google Scholar 

  21. Sterley, T.L., Howells, F.M., and Russell, V., Brain Res., 2013, vol. 1541, pp. 52–60.

    Article  CAS  Google Scholar 

  22. Edden, R.A.E., Crocetti, D., Zhu, H., Gilbert, D.L., and Mostofsky, S.H., Arch. Gen. Psychiatry, 2012, vol. 69, pp. 750–753.

    Article  CAS  Google Scholar 

  23. Schur, R.R., Draisma, L.W.R., Wijnen, J.P., Boks, M.P., Koevoets, M.G.J.C., Joels, M., Klomp, D.W., Kahn, R.S., and Vinkers, C.H., Hum. Brain Mapp., 2016, vol. 37, pp. 3337–3352.

    Article  Google Scholar 

  24. Radl, D., Chiacchiaretta, M., Lewis, R.G., Brami-Cherrier, K., Arcuri, L., and Borrelli, E., Proc. Natl. Acad. Sci. U.S.A., 2018, vol. 115, no. 1, pp. 198–203.

    Article  CAS  Google Scholar 

  25. Partyka, A., Klodzińska, A., Szewczyk, B., Wierońska, J.M., Chojnacka-Wójcik, E., Librowski, T., Filipek, B., Nowak, G., and Pilc, A., Pharmacol. Rev., 2007, vol. 59, no. 6, pp. 757–762.

    CAS  Google Scholar 

  26. Montgomery, K.C., J. Comp. Physiol. Psychol., 1955, vol. 48, no. 4, pp. 254–260.

    Article  CAS  Google Scholar 

Download references

Funding

This study was performed in accordance with the state assignment of the Ministry of Education and Science of the Russian Federation, no. 0521-2019-0009.

Author information

Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, ul. Baltiiskaya, 8, 125315, Moscow, Russia

    G. I. Kovalev, R. M. Salimov, N. A. Sukhorukova, E. A. Kondrakhin & E. V. Vasil’eva

Authors
  1. G. I. Kovalev
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Salimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. A. Sukhorukova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. A. Kondrakhin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. V. Vasil’eva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. I. Kovalev.

Ethics declarations

Conflict of interest. The authors declare no conflict of interest.

Ethical approval. The organization of the experiments corresponded to the ethical norms regulating experiments in animals suggested in the European Convention for the protection of vertebrates used for experiments or for other scientific purposes, EST no. 123, March 18, 1986, Strasbourg and the “Rules of good laboratory practice”, approved by the order of the Ministry of health of the Russian Federation no. 199n, April 1, 2016).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kovalev, G.I., Salimov, R.M., Sukhorukova, N.A. et al. Neuroreceptor Profile and Behavior of CD-1 Mice Subpopulations with Different Attention Stability. Neurochem. J. 14, 13–19 (2020). https://doi.org/10.1134/S1819712420010146

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1819712420010146

Keywords:

Search

Navigation