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Crystal Structure of 5ʹ-Oxospiro-(fluorene-9,4ʹ-imidazolidine)-2ʹ-thione and Biological Activity of Its Derivatives

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Abstract

The presented study is devoted to the structural and biological properties of four derivatives of fluorenylspirohydantoin based on experimental data. The crystal structure of one of those, (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), is described. The compound crystallizes in monoclinic crystal system and P21/c space group. We have pursued isolation of single crystals and biological activity tests of (9ʹ-fluorene)-spiro-5-hydantoin, (9ʹ-fluorene)-spiro-5-(2,4-dithiohydantoin), (9ʹ-fluorene)-spiro-5-(2-thiohydantoin), and (4ʹ,5ʹ-diaza-9ʹ-fluorene)-spiro-5-hydantoin. The compounds have been tested in both adherent and suspension tumor cell lines. The cell proliferation has been assessed by the WST-assay (Roche Applied Science). The antimicrobial activity against both Gram-positive, Gram-negative bacteria, and the yeast Candida albicans has been studied.

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ACKNOWLEDGMENTS

We are grateful to professor Plamen Penchev, PhD, DSc, of University of Plovdiv for spectra measurements.

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Authors and Affiliations

  1. Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, 4000, Plovdiv, Bulgaria

    P. Marinova

  2. Department of Chemistry and Phytopharmacy, Faculty of Plant Protection and Agroecology, Agricultural University – Plovdiv, 4000, Plovdiv, Bulgaria

    M. Marinov

  3. Department of Medical Biology, Medical University – Plovdiv, 4002, Plovdiv, Bulgaria

    M. Kazakova, Y. Feodorova & V. Sarafian

  4. University of Food Technologies, Department of Microbiology, 4002, Plovdiv, Bulgaria

    D. Blazheva & A. Slavchev

  5. Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    H. Sbirkova-Dimitrova

  6. University of Ruse – Razgrad Branch, Department of Chemical, Food and Biotechnologies, 7200, Razgrad, Bulgaria

    N. Stoyanov

  7. Research Institute at Medical University of Plovdiv, 4002, Plovdiv, Bulgaria

    M. Kazakova, Y. Feodorova & V. Sarafian

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  1. P. Marinova
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Marinova, P., Marinov, M., Kazakova, M. et al. Crystal Structure of 5ʹ-Oxospiro-(fluorene-9,4ʹ-imidazolidine)-2ʹ-thione and Biological Activity of Its Derivatives. Russ J Gen Chem 91, 939–946 (2021). https://doi.org/10.1134/S1070363221050273

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