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An Efficient Synthesis and Antimicrobial Activity of 5-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-bromophenyl}isoxazoles

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Abstract

A novel series of 1,2,3-triazolyl isoxazole derivatives is synthesized from the corresponding propargylated isoxazoles and a number of aryl azides by the Click reaction. The highest yields of the reaction are achieved in the presence of copper sulphate pentahydrate and sodium ascorbate, and using DMF:water (2:1) as a medium. The compounds structures are elucidated from various spectral data. Antimicrobial activity tests of the title compounds demonstrate their moderate to good results compared to the standard.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, 500007, India

    K. Thotla, V. Giri Noole, B. Kedika & K. Reddy

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  1. K. Thotla
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  2. V. Giri Noole
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  3. B. Kedika
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  4. K. Reddy
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Correspondence to K. Reddy.

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Thotla, K., Giri Noole, V., Kedika, B. et al. An Efficient Synthesis and Antimicrobial Activity of 5-{2-[(1-Aryl-1H-1,2,3-triazol-4-yl)methoxy]-5-bromophenyl}isoxazoles. Russ J Gen Chem 89, 789–793 (2019). https://doi.org/10.1134/S1070363219040248

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  • DOI: https://doi.org/10.1134/S1070363219040248

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