Abstract
This retrospective study determines the prevalence of anencephaly in the region of Rijeka, Croatia. Records of all spontaneous and therapeutic abortions terminated in medical institutions, all fetuses weighing more than 500 g or more than 22 weeks gestation (whether the product of abortion, therapeutic termination, stillborn or liveborn) and infants who died in the first year of life in the region of Rijeka, Croatia, during the 1963–2000 period were reviewed. There were 135,451 births; 22 of them were anencephalics (19 stillborn), which comprises 0.2% of all births and 2.1% of stillbirths. Annual prevalence of anencephaly varied in range from 0.00 to 7.42 per 10,000 births. In two cases pregnancy was electively terminated after ultrasonographic diagnosis of anencephaly. Fifteen anencephalics were female, six were male, and in one case sex was undetermined due to aplasia of genital organs. Associated congenital malformations were detected in 18 anencephalics. The importance of establishing national and international registers of congenital malformations in all countries is stressed. The authors suggested that the setting of obligatory reporting of all congenital malformations would be the first step toward this practice in Croatia, as well as in other developing countries.
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Kjaer I, Hansen BF, Keeling JW. Axial skeleton and pituitary gland in human fetuses with spina bifida and cranial encephalocele. Pediatr Pathol Lab Med 1996; 16: 909–926.
Nakano KK. Anencephaly: A review. Dev Med Child Neurol 1973; 15: 383–400.
Golden JA, Chernoff GF. Multiple sites of anterior neural tube closure in humans: Evidence from anterior neural tube defects (anencephaly). Pediatrics 1995; 95: 506–510.
Winsor SH, McGrath MJ, Khalifa M, Duncan AM. A report of recurrent anencephaly with trisomy 2p23-2pter: Additional evidence for the involvement of 2p24 in neural tube development and evaluation of the role for cytogenetic analysis. Prenat Diagn 1997; 17: 665–669.
Bound JP, Harvey PW, Francis BJ, et al. Involvement of deprivation and environmental lead in neural tube defects: A matched case-control study. Arch Dis Child 1997; 76: 107–112.
Neuhouser ML, Beresford SA, Hickok DE, Monsen ER. Absorption of dietary and supplemental folate in women with prior pregnancies with neural tube defects and controls. J Am Coll Nutr 1998; 17: 625–630.
Dolk H, De Wals P, Gillerot Y, et al. Heterogeneity of neural tube defects in Europe: The significance of site of defect and presence of other major anomalies in relation to geographic differences in prevalence. Teratology 1991; 44: 547–559.
Lewis DP, Van Dyke DC, Stumbo PJ, Berg MJ. Drug and environmental factors associated with adverse pregnancy outcomes part II: Improvement with folic acid. Ann Pharmacother 1998; 32: 947–961.
Xiao KZ. Epidemiology of neural tube defects in China. Chung Hua I Hsueh Tsa Chih 1989; 69: 189–191.
Buccimazza SS, Molteno CD, Dunne TT, Viljoen DL. Prevalence of neural tube defects in Cape Town, South Africa. Teratology 1994; 50: 194–199.
Canfield MA, Annegers JF, Brender JD, Cooper SP, Greenberg F. Hispanic origin and neural tube defects in Houston/Harris County, Texas. I. Descriptive epidemiology. Am J Epidemiol 1996; 143: 1–11.
Lary JM, Edmonds LD. Prevalence of spina bifida at birth — United States, 1983–1990: A comparison of two surveillance systems. Mor Mortal Wkly Rep CDC Surveill Summ 1996; 45: 15–26.
Dudin A. Neural tube defect among Palestinians: A hospital-based study. Ann Trop Paediatr 1997; 17: 217–222.
Luyendijk W, Treffers PD. The smile in anencephalic infants. Clin Neurol Neurosurg 1992; 94(Suppl): S113–S117.
Lary JM, Edmonds LD. Prevalence of spina bifida at birth — United States, 1983–1990: A comparison of two surveillance systems. Mor Mortal Wkly Rep CDC Surveill Summ 1996; 45: 15–26.
Borman B, Cryer C. Fallacies of international and national comparisons of disease occurrence in the epidemiology of neural tube defects. Teratology 1990; 42: 405–412.
Podobnik M. Intrauterine growth of anencephalic fetuses. Lijec Vjesn 1986; 108: 301–304.
Velisavljev MD, Nikolic-Dovat V, Gavrilovic Z, et al. Urodjene i prirodjene mane u dece severne Backe: Subotica-Senta-Backa Topola. Medicinski pregled Novi Sad. 1983: 95–99.
Kurjak A. Perinatalna medicina. Zagreb: Medicinska naklada — Zagreb, 1977.
Lewis DP, Van Dyke DC, Stumbo PJ, Berg MJ. Drug and environmental factors associated with adverse pregnancy outcomes. Part II: Improvement with folic acid. Ann Pharmacother 1998; 32: 947–961.
Iioki LH, Azika ME, Ikourou-Yoka P, Bouramoue V. Anencephaly. 10 cases seen in 3 years in Brazzaville. J Gynecol Obstet Biol Reprod (Paris) 1993; 22: 621–624.
Airede KI. Neural tube defects in the middle belt of Nigeria. J Trop Pediatr 1992; 38: 27–30.
EUROCAT Working Group. Prevalence of neural tube defects in 20 regions of Europe and the impact of prenatal diagnosis, 1980–1986. J Epidemiol Comm Health 1991; 45: 52–58.
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Loncarek, K., Mustac, E., Frkovic, A. et al. Prevalence of anencephaly in the region of Rijeka, Croatia. Eur J Epidemiol 17, 241–244 (2001). https://doi.org/10.1023/A:1017981815982
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DOI: https://doi.org/10.1023/A:1017981815982