Abstract
A mathematical model is constructed to study promiscuous coupling of receptors to G-proteins and to simulate events leading to the activation of multiple effector pathways within a cell. The model is directed at a better understanding of the factors that determine the efficacy and potency of a drug. Assuming that the receptors can exist in multiple conformational states, and allowing for agonist specific conformation, a system of ordinary differential equations is constructed and subsequently pathway-dependent agonist efficacy and potency order is predicted. A simple case of the compartmentalization of receptors and G-proteins is also given, using the current model to illustrate the effects of spatial heterogeneity on the predicted response.
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Chen, C.Y., Cordeaux, Y., Hill, S.J. et al. Modelling of signalling via G-protein coupled receptors: Pathway-dependent agonist potency and efficacy. Bull. Math. Biol. 65, 933–958 (2003). https://doi.org/10.1016/S0092-8240(03)00055-7
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DOI: https://doi.org/10.1016/S0092-8240(03)00055-7