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Mass Spectrometry-Based Omics and Imaging Technique: A Novel Tool for Molecular Toxicology and Health Impacts

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Abstract

Mass spectrometry (MS)-based omics and MS imaging (MSI) technique have been adopted as a powerful analytical strategy to investigate the toxicological effect on human health and molecular mechanism of environmental pollutants. In contrast to conventional toxicological methodologies, MS-based omics and MSI technique provides the possibility to analysis a plenty of molecules in qualitative, quantitative and spatial distribution variation including parent compounds and their metabolites as well as related endogenous metabolome, lipidome and proteome. In this perspective, we showcase the progress in MS-based omics analysis and MSI, and highlight sample preparation, high-throughput screening, data mining and more which are critical to the success of acquiring the exogenous exposure-induced molecule profiling variation and effective risk assessment method at the cellular and organ scale. The aim of this review is to contribute to a better understanding of potential molecule toxicity, pathological findings and action mechanisms caused by pollutant exposure, avoiding the environmental damage on human health if possible.

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Data Availability

All data generated or analyzed during this study are included in this published article.

Abbreviations

AFADESI-MSI:

Ambient air flow-assisted desorption electrospray ionization-mass spectrometry imaging

AP-MALDI MSI:

Atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry imaging

AUC:

Area under the curve

BADGE·2HCl:

Bisphenol A bis(3-chloro-2- hydroxypropyl) ether

BPA:

Bisphenol A

BPAP:

Bisphenol AP

BPB:

Bisphenol B

BPE:

Bisphenol E

BPF:

Bisphenol F

BPS:

Bisphenol S

BPs:

Bisphenols (including BPA, BPS, BPF, etc.)

CE-TOF/MS:

Capillary electrophoresis time-of-flight mass spectrometry

CE-MS:

Capillary electrophoresis-mass spectrometry

DESI:

Desorption electrospray ionization

DG:

Diacylglycerol

FFPE:

Formaldehyde-fixated and paraffin-embedded

FT-ICR:

Fourier transform-ion cyclotron resonance

GC–MS:

Gas chromatography mass spectrometry

GLs:

Glycerolipids

GPs:

Glycerophospholipids

IMS:

Ion mobility spectrometry

iTRAQ:

Isobaric tags for relative and absolute quantification

LA-ICP MSI:

Laser ablation inductively coupled plasma mass spectrometry imaging

LC-HRMS:

Liquid chromatography-high resolution mass spectrometry

LC–MS:

Liquid chromatography mass spectrometry

LPC:

Lysophosphatidylcholine

LPE:

Lysophosphatidylethanolamine

MALD:

Matrix-assisted laser desorption ionization

MBP:

4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene

MS:

Mass spectrometry

MS/MS:

Tandem mass spectrometry

MSI:

Mass spectrometry imaging

NOAEL:

No-observed adverse effect level

PC:

Phosphatidylcholine

PCA:

Principal component analysis

PE:

Phosphatidylethanolamine

PI:

Phosphatidylinositols

PLSA:

Probabilistic latent semantic analysis

PM2.5:

Particulate matters with aerodynamic diameter less than 2.5 μm

ROS:

Reactive oxygen species

SIMS:

Secondary ion mass spectrometry

SM-Cer:

Sphingomyelin-ceramide

TBBPA:

Tetrabromo bisphenol A

TCBPA:

Tetrachloro bisphenol A

TDI:

Tolerable daily intake

TG:

Triacylglycerol

TOF:

Time-of-flight

T2DM:

Type 2 diabetes mellitus

UFPs:

Ultrafine particles

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Acknowledgements

The work was supported by the National Key Research Program of China (2018YFA0901104), the National Natural Science Foundation of China (22176195), the Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression (ZDSYS20220606100606014), the Guangdong Province Zhu Jiang Talents Plan (2021QN02Y028), the Natural Science Foundation of Guangdong Province, China (2021A1515010171), the Key Program of Fundamental Research in Shenzhen (JCYJ20210324115811031), the Sustainable Development Program of Shenzhen (KCXFZ202002011008124).

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  1. Bionic Sensing and Intelligence Center, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Chao Zhao

  2. State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong SAR, China

    Chao Zhao & Zongwei Cai

  3. University of Chinese Academy of Sciences, Beijing, China

    Chao Zhao

  4. Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

    Chao Zhao

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Zhao, C., Cai, Z. Mass Spectrometry-Based Omics and Imaging Technique: A Novel Tool for Molecular Toxicology and Health Impacts. Reviews Env.Contamination (formerly:Residue Reviews) 261, 10 (2023). https://doi.org/10.1007/s44169-023-00032-2

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