Abstract
Acetaminophen-induced drug-induced acute liver injury is a liver disease which is one of the most serious human health diseases. Dehydroandrographolide is a natural product found in Andrographis paniculata (Burm.f.) Wall., Acanthaceae, with therapeutical uses such as analgesic and hepatoprotective. The present study was designed to analyze the effect of dehydroandrographolide on acetaminophen-induced acute liver failure. The results showed that dehydroandrographolide attenuated the damage caused by acetaminophen-induced acute liver failure in C57BL/6 mice through a decreased level of serum aspartate aminotransferase and glutamic-pyruvic transaminase. In addition, dehydroandrographolide increased the levels of glutathione and significantly increased serum superoxide dismutase. In vitro, dehydroandrographolide significantly activating nuclear-related factor 2, glutamate-cysteine ligase, glutamate-cysteine ligase modifier, heme oxygenase-1, and NAD(P)H quinone dehydrogenase 1 proteins promoted the phosphorylation of acetyl-CoA carboxylase, and 5′ adenosine monophosphate–activated protein kinase (α and β), inhibited the phosphorylation of phosphoinositide 3-kinase, serine/threonine kinase, and mammalian target of rapamycin. These results suggest that dehydroandrographolide can improve acetaminophen-induced drug-induced acute liver failure in mice.
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Data Availability
The data that support the findings of this study are available from the corresponding author, [F. H], upon reasonable request.
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This study was supported by grants from the National Natural Science Foundation of China (No. 31970507, No. 32273059).
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LD and YW: writing—original draft preparation, preliminary revision. WT and HF: conceptualization, supervision. HY, LZ and JC: methodology and suggestions. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors have approved the final revised manuscript.
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All mice studies conformed to the US National Institutes of Health (NIH) and the Guide for the Care and Use of Laboratory Animals and were authorized by the ethnical regulations of Jilin University (Number: ALKT202112003).
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Ding, L., Tan, W., Wei, Y. et al. Dehydroandrographolide Improvement of Acetaminophen-Induced Acute Liver Failure. Rev. Bras. Farmacogn. 33, 523–533 (2023). https://doi.org/10.1007/s43450-023-00376-9
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DOI: https://doi.org/10.1007/s43450-023-00376-9