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Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction

  • Reproductive Endocrinology: Review
  • Published:
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Abstract

Male fertility and metabolic disorders, including obesity and diabetes, are closely connected. Since hyperuricemia and metabolic syndrome are strongly related, male fertility and hyperuricemia may, to some degree, be associated. According to recent studies, hyperuricemia imposes various effects on sex hormones, semen quality, and male erectile dysfunction. Some researchers claim that uric acid worsens male semen and raises the risk of erectile dysfunction (ED), while others state that it safeguards both penile erection and male semen. Additionally, it has been shown that gout and metabolic syndrome also raise the risk of ED. To clarify this controversy, the influence and potential mechanisms of hyperuricemia on ED, semen quality, sex hormone levels, and the effects of hyperuricemia-related disorders on ED will be comprehensively summarized.

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Data Availability

The datasets generated during and/or analyzed the current study are publicly available.

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Acknowledgements

We thank Ya-Ru Liu (Beijing Hanyi International Culture Communication Co., Ltd) for her contribution in figure design and edit.

Funding

This work was supported by the National Natural Science Foundation of China (82174154).

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Authors and Affiliations

  1. Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Ya-Fei Liu, Huan-Huan Wang & Yin-Hong Geng

  2. Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Liang Han & Sheng-Hao Tu

  3. The Reproduction Center, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, China

    Jian-She Chen

  4. The Reproduction Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Cai-Yuzhu Wen

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Liu, YF., Wang, HH., Geng, YH. et al. Uncovering the Potential Mechanisms and Effects of Hyperuricemia and its Associated Diseases on Male Reproduction. Reprod. Sci. (2024). https://doi.org/10.1007/s43032-024-01453-7

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