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Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70

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Abstract

Inflammation is a common feature of aging tissues, being involved in most, if not all, age-related diseases. The origin of a low-grade inflammation state in aging (inflammaging) is multifactorial and may involve changes in body composition, immunosenescence, autophagy, microbiota modification and loss of proteostasis. The heat shock response pathway (HSR, and HSP70 expression) plays an important role as a mechanism of resolution of inflammation and proteostasis control. In this review, we sought to discuss the mechanisms that may lead to inflammaging, and the importance of the HSP70 in this process. Besides, we also discuss how physical exercise, particularly resistance training, can improve the HSR and the inflammatory balance of elderly people.

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Acknowledegments

We thank the Federal University of Rio Grande do Sul (UFRGS), Department of Physiology and the School of Physical Education of UFRGS, for supporting this work.

Funding

This work was supported by FAPERGS and CNPq. Mauricio Krause received grant support from FAPERGS (Edital FAPERGS/Decit/SCTIE/MS/CNPq/SESRS n. 03/2017-PPSUS #17/2551-0001424-3).

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Authors and Affiliations

  1. Laboratory of Inflammation, Metabolism and Exercise Research (LAPIMEX) and Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Sarmento Leite Street, 500, Lab 02, 90050-170, Porto-Alegre, RS, Brazil

    Carlos Henrique de Lemos Muller, Jorge Roberto de Matos, Gisele Bettú Grigolo, Helena Trevisan Schroeder & Mauricio Krause

  2. School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Josianne Rodrigues-Krause

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  1. Carlos Henrique de Lemos Muller
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Correspondence to Mauricio Krause.

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de Lemos Muller, C.H., de Matos, J.R., Grigolo, G.B. et al. Exercise Training for the Elderly: Inflammaging and the Central Role for HSP70. J. of SCI. IN SPORT AND EXERCISE 1, 97–115 (2019). https://doi.org/10.1007/s42978-019-0015-6

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