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Highly sensitive and selective non-enzymatic uric acid electrochemical sensor based on novel polypyrrole-carbon black-Co3O4 nanocomposite

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Abstract

Efficient uric acid (UA) detection from the blood serum is a key indicator of overall health status and thus helps in public health monitoring. Hence, in this article, we have proposed a non-enzymatic UA sensor using a novel polypyrrole-carbon black-Co3O4 (PPy-CB-Co3O4) nanocomposite (NC) modified glassy carbon electrode. Modern analytical tools like FE-SEM, TEM, EDXS, XRD, XPS, and FTIR spectroscopy were used to characterize the PPy-CB-Co3O4 nanocomposite. XRD and XPS analysis confirmed the fruitful development of nanocomposite consisting of PPy-CB and Co3O4. TEM images revealed that Co3O4 nanoparticles (NPs) were randomly dispersed on the PPy-CB sheets. In the electrochemical investigations, PPy-CB-Co3O4/GCE sensor showed excellent sensitivity (0.8786 μA μM−1 cm−2), wide LDR (0.75–305 μM) to cover the entire UA range in human blood serum, and extremely lower detection limit (LOD ~ 0.46 μM). The newly developed UA sensor was further used to check the potential chemical interference using several biomolecules, presenting an extreme selectivity in UA detection. The PPy-CB-Co3O4/GCE sensor also exhibited satisfactory results in detecting UA levels in human blood serum. In UA determination, the PPy-CB-Co3O4/GCE sensor also displayed excellent reproducibility, repeatability, and stability. It is anticipated that this PPy-CB-Co3O4 nanocomposite fabricated GCE will emerge as an effective route to develop an efficient non-enzymatic UA sensor.

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Acknowledgements

The authors are thankful to the Deanship of Scientific Research at Najran University, Kingdom of Saudi Arabia for funding this work through a Grant: Research code NU/-/SERC/10/523. We also acknowledge Najran University Hospital for providing human blood serum samples. Jahir Ahmed acknowledges support from the Research and Development Office, the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia, in cooperation with Najran University in the form of a postdoctoral fellowship.

Funding

This research was supported by the Deanship of Scientific Research at Najran University, Kingdom of Saudi Arabia through a Grant: Research code NU/-/SERC/10/523.

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Authors and Affiliations

  1. Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, P.O. Box: 1988, Najran, 11001, Saudi Arabia

    Jahir Ahmed, M. Faisal, S. A. Alsareii & Farid A. Harraz

  2. Department of Chemistry, Faculty of Science and Arts, Najran University, Najran, Saudi Arabia

    M. Faisal

  3. Department of Surgery, College of Medicine, Najran University, Najran, Saudi Arabia

    S. A. Alsareii

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  1. Jahir Ahmed
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  2. M. Faisal
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  3. S. A. Alsareii
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  4. Farid A. Harraz
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Correspondence to Farid A. Harraz.

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Ahmed, J., Faisal, M., Alsareii, S.A. et al. Highly sensitive and selective non-enzymatic uric acid electrochemical sensor based on novel polypyrrole-carbon black-Co3O4 nanocomposite. Adv Compos Hybrid Mater 5, 920–933 (2022). https://doi.org/10.1007/s42114-021-00391-1

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  • DOI: https://doi.org/10.1007/s42114-021-00391-1

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