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How does exosome cause diabetes?

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Abstract

Exosomes are extracellular vesicles that are widely distributed in multiple cell types and circulating body fluids. They have a specific effect on the target cells by releasing different vesicle contents. They have recently been recognized as important means of intercellular communication, being involved, for example, in the development of diabetes by increasing β-cell apoptosis, activating autoimmunity, and regulating cytokines to affect islet β-cell function and insulin sensitivity. An in-depth study of the role of exosome in the pathogenesis of diabetes may therefore provide a novel means of diagnosing and treating diabetes. In this review, we detail how exosome is involved in the development of diabetes.

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Authors and Affiliations

  1. Cixi Biomedical Research Institute, Wenzhou Medical University, Cixi, Ningbo, China

    Fei Hu

  2. Zhejiang Center of Animal Disease Control, Hangzhou, China

    Yicong Yu

  3. Department of Orthopaedic Surgery, Affiliated Cixi Hospital, Wenzhou Medical University, No. 999, South Second Ring Road, Hushan Street, Cixi, Ningbo, 315300, China

    Hongming Xu

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Correspondence to Hongming Xu.

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Hu, F., Yu, Y. & Xu, H. How does exosome cause diabetes?. Hormones (2024). https://doi.org/10.1007/s42000-024-00525-2

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