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Novel electrically conductive electrospun PCL-MXene scaffolds for cardiac tissue regeneration

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Abstract

Effective cardiac tissue regeneration necessitates scaffolds that mimic the native extracellular matrix and possess desirable properties, such as electrical conductivity and biocompatibility. The choice of an appropriate fabrication method is paramount in achieving reproducibility, scalability, and rapid production of cardiac tissue patches. Electrospinning, a versatile and widely utilized technique, offers precise control over fiber diameter, pore size, and alignment, rendering it an ideal method for creating intricate cardiac scaffolds. In light of the limitations of existing therapies and the need for innovative approaches, this research aims to explore the development of novel patches for cardiac tissue regeneration. By investigating the integration of MXenes into electrospun polycaprolactone (PCL) membranes, we aim to harness the unique properties of MXenes to create conductive, biocompatible, and mechanically robust scaffolds that promote cell adhesion, proliferation, and functional maturation. The application of oxygen plasma treatment enhances the infiltration of MXene into the PCL electrospun membrane, significantly reducing the surface contact angle and promoting cell adhesion. Regardless of the number of MXene deposition repetitions, all variants demonstrated strong biocompatibility and supported the formation of cell symplasts after fibroblast seeding. The remarkable electrical conductivity of PCL-MXene membranes, coupled with the positive biological outcomes presented in this study, has the potential to drive significant advancements in the field of cardiac tissue engineering. This research offers fresh insights and approaches to tackle the challenges associated with myocardial repair and regeneration.

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The raw/processed data required to reproduce these findings cannot be shared at this time as the data also form part of an ongoing study. The raw data are available on request.

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Acknowledgements

This research was supported by Horizon Europe MSCA-2021-SE-01 project MX-MAP (#101086184) and H2020-MSCA-RISE-2019 SALSETH (#872370) and received support from the Ministry of Education and Science of Ukraine (0122U000784).

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  1. Una Riekstina and Maksym Pogorielov are co-last authors.

Authors and Affiliations

  1. Sumy State University, 2 Rymskogo-Korsakova St, Sumy, 40007, Ukraine

    Kateryna Diedkova, Yevheniia Husak, Viktoriia Korniienko, Anton Roshchupkin, Ilya Yanko, Alexander D. Pogrebnjak, Ivan Baginskiy & Maksym Pogorielov

  2. University of Latvia, 3 Jelgavas St, Riga, 1004, Latvia

    Kateryna Diedkova, Viktoriia Korniienko, Kaspars Jekabsons, Una Riekstina & Maksym Pogorielov

  3. Faculty of Chemistry, Silesian University of Technology, 9 Strzody St, 44-100, Gliwice, Poland

    Yevheniia Husak, Wojciech Simka, Agnieszka Stolarczyk & Natalia Waloszczyk

  4. Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia

    Bojan Petrovic

  5. Centre for Nanodiagnostics of Materials, Slovak University of Technology in Bratislava, 5 Vazovova St, Bratislava, 812 43, Slovakia

    Maria Čaplovičová

  6. Faculty of Material Science in Trnava, Institute of Materials, Slovak University of Technology in Bratislava, Jana Bottu c2781/25, Trnava, Slovakia

    Alexander D. Pogrebnjak

  7. Materials Research Centre, 3 Krzhizhanovskogo St, Kyiv, 03142, Ukraine

    Veronika Zahorodna, Oleksiy Gogotsi, Iryna Roslyk & Ivan Baginskiy

  8. University of Novi Sad, BioSense Institute, Dr Zorana Djindjica 1, 21000, Novi Sad, Serbia

    Marko Radovic

  9. Faculty of Technical Sciences, University of Novi Sad, Trg Dositeja Obradovića 6, 21000, Novi Sad, Serbia

    Sanja Kojic

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  1. Kateryna Diedkova
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Contributions

K.D. - Conceptualisation, membrane preparation, cell culture, wrote the manuscript; Y. H. - contact angle, 3D visualization; W. S. - Raman, 3D visualization; V. K. - bacteriology experiment; B. Petrovic - conductivity measurements, SEM; A. R. - SEM of bacteria, 3D visualization; A. Stolarczyk - FTIR; N.Waloszczyk - Raman; I. Yanko - SEM of bacteria, figure preparation; K. Jekabsons - cell fluorescent microscopy; M. Čaplovičová - HRTEM; A.D.P. - HRTEM and manuscript writing; V. Z. - MXene preparation; O. Gogotsi -MAX-phase synthesis; I.Roslyk - MXene synthesis and delamination; I. Baginskiy - membrane impregnation of MXene; M. Radovic - electroconductivity measurement; S. Kojic - electroconductivity description; U. R. -conceptualization of biological experiment, manuscript writing; M. P. - supervision. manuscript writing and correction. All authors reviewed the manuscript.

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Correspondence to Maksym Pogorielov.

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Diedkova, K., Husak, Y., Simka, W. et al. Novel electrically conductive electrospun PCL-MXene scaffolds for cardiac tissue regeneration. Graphene and 2D mater 9, 59–76 (2024). https://doi.org/10.1007/s41127-023-00071-5

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