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Circadian Rhythm and Pain: a Review of Current Research and Future Implications

  • Sleep and Pain (M Smith, Section Editor)
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Abstract

Purpose of Review

The goal is to examine the link between circadian rhythms and pain, which may shed further light on improving pain management strategies and preventing the development and/or worsening of chronic pain.

Recent Findings

In part I, we provide evidence that the rhythmicity of pain may be regulated by the central circadian clock. We also found that rhythmicity in pain widely differs across pain conditions. In part II, we provide indirect evidence that circadian rhythm disruptions (e.g., night-shift work) and improvement of circadian synchronization (e.g., light therapy) are associated with pain-related experiences.

Summary

Investigating the link between circadian rhythms and pain may inform enhancing precision pain medicine and assay sensitivity of clinical trials, as well as development of more effective chronic pain treatment and prevention programs. More rigorous laboratory studies that evaluate endogenous circadian pain rhythmicity and through what mechanisms disrupted circadian rhythms impact pain processing are needed.

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Notes

  1. Static pain measures evaluate the sensory thresholds and tolerance to a single stimulus (e.g., pain threshold and tolerance), whereas dynamic pain measures can assess both the ascending pain facilitation and descending pain modulation of nociceptive signals (e.g., temporal summation and conditioned pain modulation) by inducing a number of painful stimuli [98].

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Authors and Affiliations

  1. Edson College of Nursing and Health Innovation, Arizona State University, Health North, Suite 301, 550 N 3rd Street, Phoenix, AZ, 85004, USA

    Chung Jung Mun, Dara James, Ulysses Altamirano, Surabhi Sajith, Ananya Lakhotia & Shawn D. Youngstedt

  2. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Chung Jung Mun

  3. Sleep and Circadian Research Laboratory, Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA

    Helen J. Burgess

  4. College of Health Solutions, Arizona State University, Phoenix, AZ, USA

    Dorothy D. Sears

  5. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Arizona, Tucson, AZ, USA

    Sairam Parthasarathy

  6. Community Mental Health Nursing Department, College of Nursing, University of South Alabama, Mobile, AL, USA

    Dara James

  7. Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA

    Roger B. Fillingim

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Dr. Burgess reports personal fees from Natrol, LLC, Moving Mindz, Pty Ltd, and F. Hoffmann-La Roche Ltd outside the submitted work. The rest of the authors declare that they have no competing interests. We would also like to note that Fig. 1 represents the original image file from the authors.

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Mun, C.J., Burgess, H.J., Sears, D.D. et al. Circadian Rhythm and Pain: a Review of Current Research and Future Implications. Curr Sleep Medicine Rep 8, 114–123 (2022). https://doi.org/10.1007/s40675-022-00228-3

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