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An event is serious (based on the ICH definition) when the patient outcome is:
* death
* life-threatening
* hospitalisation
* disability
* congenital anomaly
* other medically important event
A 46-year-old man exhibited no drug effect during treatment with venetoclax, azacitidine, fludarabine, cytarabine, idarubicin, etoposide, vincristine and vindesine for acute myeloid leukemia (AML). He exhibited lack of efficacy during treatment with fluconazole, micafungin, caspofungin for antifungal prophylaxis and amphotericin-B-liposomal, voriconazole for fungal infection caused by Candida guilliermondii and Blastobotrys mokoenaii [not all routes and dosages stated].
Reference
Shiomi I, et al. Invasive fungal infection caused by Blastobotrys mokoenaii in an immunocompromised patient with acute myeloid leukemia: A case report. Journal of Infection and Chemotherapy : Jan 2023. Available from: URL: https://dx.doi.org/10.1016/j.jiac.2023.12.002
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Multiple drugs. Reactions Weekly 1991, 160 (2024). https://doi.org/10.1007/s40278-024-52672-1
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DOI: https://doi.org/10.1007/s40278-024-52672-1