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Tryptophan and serotonin levels as potent biomarkers in diabetes mellitus complications: a new approach of diagnostic role

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Abstract

Objective

Alterations in the serotonergic system were verified to act a role in the pathogenesis of altered neurological and psychiatric diseases. In recent years, Tryptophan (Trp) and serotonin (5-HT) levels have been considered potent biomarkers of diabetes mellitus (DM).

Method

The different Trp metabolism may also play roles in the pathogenesis of DM and mounting risk of complications. The whole blood (WB) 5-HT level was mainly lower among diabetic patients compared to others. That is mostly derived from a lower platelet concentration of 5-HT in these patients.

Results

Indeed, 5-HT level can be considered a potent biomarker for early detection of DM complications. Besides, it was proved that outside the digestive and central nervous systems, 5-HT was discovered in beta cells, and scientists have been attempting to realize its mechanism of action ever since. Towards to end, the determination methods, biomarker’s role, and approaches of 5-HT and Trp levels were thoroughly investigated in both healthy and diabetic patients with or without complications. Moreover, the association between insulin and 5-HT has been specifically discussed.

Conclusions

Our study concluded that Trp and 5-HT levels could be exclusively applied for early diagnosis of DM complications as well as many other complications.

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Acknowledgements

This work was nonfinancially supported by Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences.

Funding

Private funds were applied to carry out this study.

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Authors and Affiliations

  1. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran

    Kamyar Khoshnevisan

  2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1983963113, Iran

    Kamyar Khoshnevisan

  3. Department of Surgical Technology, Paramedical School, Golestan University of Medical Sciences, Gorgan, 4934174515, Iran

    Maryam Chehrehgosha

  4. Department of Gerontology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran

    Maryam Chehrehgosha

  5. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, 1411713137, Iran

    Sayed Mahmoud Sajjadi-Jazi

  6. Department of Psychiatry, New York State Psychiatric Institute, Columbia University, New York, NY, 10032, USA

    Amir Mohammad Meftah

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  1. Kamyar Khoshnevisan
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  2. Maryam Chehrehgosha
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Contributions

KK: Conceptualization, Investigation, Methodology, Design, Writing-review &editing. MCG: Investigation, Methodology, Design, Writing-review &editing. SMSJ: Investigation, Methodology, Writing-review &editing. AMM: Investigation, Writing-review &editing.

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Correspondence to Kamyar Khoshnevisan or Sayed Mahmoud Sajjadi-Jazi.

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Kamyar Khoshnevisan and Maryam Chehrehgosha are equally contributed as first authors.

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Khoshnevisan, K., Chehrehgosha, M., Sajjadi-Jazi, S.M. et al. Tryptophan and serotonin levels as potent biomarkers in diabetes mellitus complications: a new approach of diagnostic role. J Diabetes Metab Disord 21, 1923–1934 (2022). https://doi.org/10.1007/s40200-022-01096-y

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