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Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing

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Acta Metallurgica Sinica (English Letters) Aims and scope

Abstract

Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable problem. In this study, new macroporous and antibacterial gelatin/alginate (SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel matrix. The addition of Mg-Cu particles decreased the storage modulus of SAG, maintained its mechanical resilience and enhanced its water-absorbing capability. Moreover, the water vapor transmission rate of SAG added with 2 wt.% Mg-Cu (SAG-2MC) was 124% of that of medical gauze and 804% of commercial Tegaderm™ film dressing. The bacterial inhibition rates of SAG-2MC against S. aureus, E. coli and P. aeruginosa reached 99.9% ± 0.1%, 98.7% ± 1.2% and 98.0% ± 0.7%, respectively, significantly greater than those of the SAG hydrogel and Mg particle-modified hydrogels. In addition, SAG-2MC hydrogel was biocompatible and promoted cell migration. In vivo experiment results indicated that SAG-2MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness, more collagen deposition and enhanced angiogenesis compared with SAG-0MC, SAG-2M and Tegaderm™ film. In summary, Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG hydrogels. Mg-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions.

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Acknowledgements

The authors thank the financial support from the National Natural Science Foundation of China (Nos.82025025, 51672184, 31801585, 81622032 and 32171321), National Key Research and Development Program of China (No. 2020YFC1107401), Suzhou Science and Technology Project (No. SYS2019022), China Postdoctoral Science Foundation (No. 2020T130459) and the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD).

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  1. Jiewei Yin and Pengcheng Xu have contributed equally.

Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Materials Science, Orthopedic Institute, Soochow University, Suzhou, 215006, China

    Jiewei Yin, Kang Wu, Xiao Lin & Lei Yang

  2. Department of Orthopaedics, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China

    Pengcheng Xu & Huilin Yang

  3. Center for Health Science and Engineering (CHSE), School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, 300130, China

    Huan Zhou & Lei Yang

  4. Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China

    Lili Tan & Ke Yang

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  1. Jiewei Yin
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Yin, J., Xu, P., Wu, K. et al. Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing. Acta Metall. Sin. (Engl. Lett.) 35, 853–866 (2022). https://doi.org/10.1007/s40195-021-01335-w

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