Skip to main content
SpringerLink
Log in

Fabrication and Characterizations of Metallic Mg Containing PMMA-Based Partially Degradable Composite Bone Cements

  • Published:
Acta Metallurgica Sinica (English Letters) Aims and scope

Abstract

Inadequate strength at the bone/cement interface is one of the main drawbacks of poly(methylmethacrylate) (PMMA) bone cement in the current orthopedic surgeries. In the present work, a partially degradable PMMA/Mg composite bone cement (PMC) was developed for enhancing the bone/cement interfacial strength, which is proposed to be accomplished by increasing the osteo-conductivity of PMMA and enhancing the mechanical interlocking between bone tissue and the porous PMMA surface formed by the degradation of Mg on the surface of the cement. PMCs were prepared with various concentrations of Mg particles with different sizes and alloy compositions. The effects of Mg particle size, composition and content on the injectability, mechanical and degradation properties, and biocompatibility of PMCs were evaluated. The results show that these parameters affected the properties of the PMCs simultaneously. The good injectability and compressive strengths of PMMA were preserved, while the compatibility to osteoblasts was enhanced when adding Mg particles in a proper manner. The PMCs degraded at the surface with time and formed porous surface structures in the physiological environment, while maintaining the original compressive strengths. This preliminary study shows that the PMC is promising for minimally invasive orthopedic surgery; however, it still requires to be optimized and evaluated in the future.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Y.F. Zheng, X.N. Gu, F. Witte, Mater. Sci. Eng., R 77, 1 (2014)

    Article  Google Scholar 

  2. X.N. Gu, Y.F. Zheng, Front. Mater. Sci. 4, 111 (2010)

    Article  Google Scholar 

  3. M.P. Staiger, A.M. Pietak, J. Huadmai, G. Dias, Biomaterials 27, 1728 (2006)

    Article  Google Scholar 

  4. F. Witte, Acta Biomater. 6, 1680 (2010)

    Article  Google Scholar 

  5. H. Feng, G. Wang, W. Jin, X. Zhang, Y. Huang, A. Gao, H. Wu, G. Wu, P.K. Chu, ACS Appl. Mater. Inter. 8, 9662 (2016)

    Article  Google Scholar 

  6. D.A. Robinson, R.W. Griffith, D. Shechtman, R.B. Evans, M.G. Conzemius, Acta Biomater. 6, 1869 (2010)

    Article  Google Scholar 

  7. J. Liang, R.H. Zhang, Z.J. Peng, B.X. Liu, Front. Mater. Sci. 8, 307 (2014)

    Article  Google Scholar 

  8. L.Y. Cui, X.H. Fang, W. Cao, R.C. Zeng, S.Q. Li, X.B. Chen, Y.H. Zou, S.K. Guan, E.-H. Han, Appl. Surf. Sci. 457, 49 (2018)

    Article  Google Scholar 

  9. L.Y. Cui, S.D. Gao, P.P. Li, R.C. Zeng, F. Zhang, S.Q. Li, E.-H. Han, Corros. Sci. 118, 84 (2017)

    Article  Google Scholar 

  10. R.C. Zeng, L.Y. Cui, K. Jiang, R. Liu, B.D. Zhao, Y.F. Zheng, ACS Appl. Mater. Inter. 8, 10014 (2016)

    Article  Google Scholar 

  11. Z.Y. Ding, L.Y. Cui, X.B. Chen, R.C. Zeng, S.K. Guan, S.Q. Li, F. Zhang, Y.H. Zou, Q.Y. Liu, J. Alloys. Compd. 764, 250 (2018)

    Article  Google Scholar 

  12. Y.B. Zhao, L.Q. Shi, L.Y. Cui, C.L. Zhang, S.Q. Li, R.C. Zeng, F. Zhang, Z.L. Wang, Acta Metall. Sin. (Engl. Lett.) 31, 180 (2018)

    Article  Google Scholar 

  13. J.W. Lee, H.S. Han, K.J. Han, J. Park, H. Jeon, M.R. Ok, H.K. Seok, J.P. Ahn, K.E. Lee, D.H. Lee, S.J. Yang, S.Y. Cho, P.R. Cha, H. Kwon, T.H. Nam, J.H.L. Han, H.J. Rho, K.S. Lee, Y.C. Kim, D. Mantovani, Proc. Natl. Acad. Sci. 113, 716 (2016)

    Article  Google Scholar 

  14. D. Zhao, S. Huang, F. Lu, B. Wang, L. Yang, L. Qin, K. Yang, Y. Li, W. Li, W. Wang, S. Tian, X. Zhang, W. Gao, Z. Wang, Y. Zhang, X. Xie, J. Wang, J. Li, Biomaterials 81, 84 (2016)

    Article  Google Scholar 

  15. H.M. Wong, S. Wu, P.K. Chu, S.H. Cheng, K.D.K. Luk, K.M.C. Cheung, K.W.K. Yeung, Biomaterials 34, 7016 (2013)

    Article  Google Scholar 

  16. Y.H. Cheng, Y.F. Zheng, J. Mater. Sci. Technol. 29, 545 (2013)

    Article  Google Scholar 

  17. A. Brown, S. Zaky, R.H. Jr, C. Sfeir, Acta Biomater. 11, 543 (2015)

    Article  Google Scholar 

  18. H.D. Jung, S.P. Hui, M.H. Kang, S.M. Lee, H.E. Kim, Y. Estrin, Y.H. Koh, Mater. Lett. 116, 20 (2014)

    Article  Google Scholar 

  19. P. Wan, C. Yuan, L. Tan, Q. Li, K. Yang, Compos. Sci. Technol. 98, 36 (2014)

    Article  Google Scholar 

  20. J. Saleh Khaled, M. El Othmani Mouhanad, H. Tzeng Tony, M. Mihalko William, C. Chambers Monique, M. Grupp Thomas, J. Orth. Res. 34, 737 (2016)

    Article  Google Scholar 

  21. Z. He, Q. Zhai, M. Hu, C. Cao, J. Wang, H. Yang, B. Li, J. Orthop. Transl. 3, 1 (2015)

    Google Scholar 

  22. M. Sundfeldt, L.V. Carlsson, C.B. Johansson, P. Thomsen, C. Gretzer, Acta Orthop. 77, 177 (2006)

    Article  Google Scholar 

  23. G. Lewis, J. Biomed. Mater. Res. B 38, 155 (1997)

    Article  Google Scholar 

  24. W.F. Mousa, M. Kobayashi, S. Shinzato, M. Kamimura, M. Neo, S. Yoshihara, T. Nakamura, Biomaterials 21, 2137 (2000)

    Article  Google Scholar 

  25. J.R. Goodheart, M.A. Miller, K.A. Mann, J. Orthop. Res. 32, 1052 (2014)

    Article  Google Scholar 

  26. S.J. Heo, S.A. Park, H.J. Shin, Y.J. Lee, T.R. Yoon, H.Y. Seo, K.C. Ahn, S.E. Kim, J.W. Shin, Key Eng. Mater. 342–343, 373 (2007)

    Article  Google Scholar 

  27. C. Wolf-Brandstetter, S. Roessler, S. Storch, U. Hempel, U. Gbureck, B. Nies, S. Bierbaum, D. Scharnweber, J. Biomed. Mater. Res. B 101B, 599 (2013)

    Article  Google Scholar 

  28. M. Khandaker, Y. Li, T. Morris, J. Biomech. 46, 1035 (2013)

    Article  Google Scholar 

  29. X. Lin, S. Yang, K. Lai, H. Yang, T.J. Webster, L. Yang, Nanomed. Nanotechnol. Biol. Med. 13, 123 (2017)

    Article  Google Scholar 

  30. X. Lin, L. Tan, Q. Zhang, K. Yang, Z. Hu, J. Qiu, Y. Cai, Acta Biomater. 9, 8631 (2013)

    Article  Google Scholar 

  31. I. Goñi, R. Rodríguez, I. García-Arnáez, J. Parra, M. Gurruchaga, J. Biomed. Mater. Res. B 106, 1245 (2017)

    Article  Google Scholar 

  32. S.B. Kim, Y.J. Kim, T.L. Yoon, S.A. Park, I.H. Cho, E.J. Kim, I.A. Kim, J.-W. Shin, Biomaterials 25, 5715 (2004)

    Article  Google Scholar 

  33. H. Tan, S. Guo, S. Yang, X. Xu, T. Tang, Acta Biomater. 8, 2166 (2012)

    Article  Google Scholar 

  34. C. Fukuda, K. Goto, M. Imamura, M. Neo, T. Nakamura, Acta Biomater. 7, 3595 (2011)

    Article  Google Scholar 

  35. X. Lin, X. Yang, L. Tan, M. Li, X. Wang, Y. Zhang, K. Yang, Z. Hu, J. Qiu, Appl. Surf. Sci. 288, 718 (2014)

    Article  Google Scholar 

  36. Z. Li, X. Gu, S. Lou, Y. Zheng, Biomaterials 29, 1329 (2008)

    Article  Google Scholar 

  37. B.J. Wang, D.K. Xu, J.H. Dong, W. Ke, J. Mater. Sci. Technol. 34, 1756 (2018)

    Article  Google Scholar 

  38. L.Y. Cui, Y. Hu, R.C. Zeng, Y.X. Yang, D.D. Sun, S.Q. Li, F. Zhang, E.-H. Han, J. Mater. Sci. Technol. 33, 971 (2017)

    Article  Google Scholar 

  39. L. Yang, E. Zhang, Mater. Sci. Eng., C 29, 1691 (2009)

    Article  Google Scholar 

  40. W.F. Ng, K.Y. Chiu, F.T. Cheng, Mater. Sci. Eng., C 30, 898 (2010)

    Article  Google Scholar 

  41. S.B. Kim, Y.J. Kim, T.L. Yoon, A.P. Su, I.H. Cho, E.J. Kim, I.A. Kim, J.W. Shin, Biomaterials 25, 5715 (2004)

    Article  Google Scholar 

  42. G. Lewis, J. Biomed. Mater. Res. B 98B, 171 (2011)

    Article  Google Scholar 

  43. D. Xia, Y. Liu, S. Wang, R.C. Zeng, Y. Liu, Y. Zheng, Y. Zhou, Sci. China Mater. (2018). https://doi.org/10.1007/s40843-018-9293-8

  44. R.C. Zeng, L. Sun, Y.F. Zheng, H.Z. Cui, E.-H. Han, Corros. Sci. 79, 69 (2014)

    Article  Google Scholar 

  45. C. Shuai, L. Liu, M. Zhao, P. Feng, Y. Yang, W. Guo, C. Gao, F. Yuan, J. Mater. Sci. Technol. 34, 1944 (2018)

    Article  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81501858, 81622032, 51501109 and 51672184), the Principal Project of Natural Science Research of Jiangsu Higher Education Institutions (No. 17KJA180011), Jiangsu Innovation and Entrepreneurship Program, and the Priority Academic Program Development of Jiangsu High Education Institutions (PAPD).

Author information

Authors and Affiliations

  1. Orthopaedic Institute, Soochow University, Suzhou, 215006, China

    Xiao Lin, Hui-Lin Yang & Lei Yang

  2. Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China

    Xiao Lin, Hui-Lin Yang & Lei Yang

  3. Waterloo Institute for Nanotechnology (WIN), University of Waterloo, 200 University Ave West, Waterloo, ON, Canada

    Adrian Chan

  4. School of Materials Engineering, Shanghai University of Science and Engineering, Shanghai, 201620, China

    Xiao-Xiao Tan

Authors
  1. Xiao Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adrian Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiao-Xiao Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hui-Lin Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lei Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lei Yang.

Additional information

Available online at http://link.springer.com/journal/40195

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, X., Chan, A., Tan, XX. et al. Fabrication and Characterizations of Metallic Mg Containing PMMA-Based Partially Degradable Composite Bone Cements. Acta Metall. Sin. (Engl. Lett.) 32, 808–816 (2019). https://doi.org/10.1007/s40195-018-0841-2

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40195-018-0841-2

Keywords

Search

Navigation