Skip to main content
Log in

Pediatric Unilateral Vocal Fold Paralysis: Workup and Management

  • LARYNGOLOGY: Management of Vocal Cord Paralysis (D Chhetri and JL Long, Section Editors)
  • Published:
Current Otorhinolaryngology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This paper will examine recent advances in the assessment and management of pediatric unilateral vocal fold motion impairment (VFMI).

Recent Findings

Unilateral VFMI can have a considerable impact on pediatric voice, swallowing, and pulmonary hygiene. In addition, postoperative VFMI in children undergoing congenital cardiac procedures is associated with longer lengths of stay. Laryngeal ultrasound (LUS) is an adjunctive tool that can be used to assess vocal fold mobility in patients who cannot tolerate traditional flexible nasolaryngoscopy (FNL) or for those in whom FNL is non-diagnostic. Laryngeal electromyography (LEMG) can help differentiate neuronal causes of vocal fold paralysis from mechanical cricoarytenoid joint fixation. Recent data suggests that preoperative LEMG may be used to predict voice outcomes after non-selective laryngeal reinnervation (NSLR). NSLR is a promising treatment modality for permanent vocal fold medialization in children.

Summary

An emphasis on early diagnostic and prognostic techniques, such as the use of LUS and LEMG, can inform decision-making in unilateral VFMI treatment. NSLR is emerging as the preferred treatment modality for pediatric unilateral VFMI due to neuronal injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Connor NP, Cohen SB, Theis SM, Thibeault SL, Heatley DG, Bless DM. Attitudes of children with dysphonia. J Voice. 2008;22:197–209.

    Article  Google Scholar 

  2. Spieth LE, Harris CV. Assessment of health-related quality of life in children and adolescents. J Pediatr Psychol. 1996;21:175–93.

    Article  CAS  Google Scholar 

  3. Zur KB, Cotton S, Kelchner L, Baker S, Weinrich B, Lee L. Pediatric Voice Handicap Index (pVHI): a new tool for evaluating pediatric dysphonia. Int J Pediatr Otorhinolaryngol. 2007;71:77–82.

    Article  Google Scholar 

  4. Boseley ME, Cunningham MJ, Volk MS, Hartnick CJ. Validation of the pediatric voice-related quality-of-life survey. Arch Otolaryngol Head Neck Surg. 2006;132:717–20.

    Article  Google Scholar 

  5. Hartnick CJ. Validation of a pediatric voice quality-of-life instrument: the pediatric voice outcome survey. Arch Otolaryngol Head Neck Surg. 2002;128:919–22.

    Article  Google Scholar 

  6. Jabbour J, Martin T, Beste D, Robey T. Pediatric vocal fold immobility: natural history and the need for long-term follow-up. JAMA Otolaryngol - Head Neck Surg. 2014;140:428–33.

    Article  Google Scholar 

  7. Irace AL, Dombrowski ND, Kawai K, Dodrill P, Perez J, Hernandez K, et al. Aspiration in children with unilateral vocal fold paralysis. Laryngoscope. 2019;129:569–73.

    Article  Google Scholar 

  8. Truong MT, Messner AH, Kerschner JE, Scholes M, Wong-Dominguez J, Milczuk HA, et al. Pediatric vocal fold paralysis after cardiac surgery: rate of recovery and sequelae. Otolaryngol Head Neck Surg. 2007;137:780–4.

    Article  Google Scholar 

  9. Ambrose SE, Ongkasuwan J, Dedhia K, Diercks GR, Anne S, Shashidharan S, et al. Analysis of vocal fold motion impairment in neonates undergoing congenital heart surgery. JAMA Otolaryngol - Head Neck Surg. 2018;144:406–12.

    Article  Google Scholar 

  10. Dewan K, Cephus C, Owczarzak V, Ocampo E. Incidence and implication of vocal fold paresis following neonatal cardiac surgery. Laryngoscope. 2012;122:2781–5.

    Article  Google Scholar 

  11. Richter AL, Ongkasuwan J, Ocampo EC. Long-term follow-up of vocal fold movement impairment and feeding after neonatal cardiac surgery. Int J Pediatr Otorhinolaryngol. Elsevier Ireland Ltd;. 2016;83:211–4. https://doi.org/10.1016/j.ijporl.2016.02.014.

    Article  PubMed  Google Scholar 

  12. Raol N, Schrepfer T, Hartnick C. Aspiration and dysphagia in the neonatal patient. Clin Perinatol. Elsevier Inc;. 2018;45:645–60. https://doi.org/10.1016/j.clp.2018.07.005.

    Article  PubMed  Google Scholar 

  13. Wang LM, Zhu Q, Ma T, Li JP, Hu R, Rong XY, et al. Value of ultrasonography in diagnosis of pediatric vocal fold paralysis. Int J Pediatr Otorhinolaryngol. 2011;75:1186–90.

    Article  CAS  Google Scholar 

  14. • Ongkasuwan J, Ocampo E, Tran B. Laryngeal ultrasound and vocal fold movement in the pediatric cardiovascular intensive care unit. Laryngoscope. 2017;127:167–72 Findings from this study suggest laryngeal ultrasound is a comparable alternative to flexible nasolaryngoscopy to evaluate vocal fold mobility with decreased physiologic impact.

    Article  Google Scholar 

  15. Vats A, Worley GA, De Bruyn R, Porter H, Albert DM, Bailey CM. Laryngeal ultrasound to assess vocal fold paralysis in children. J Laryngol Otol. 2004;118:429–31.

    Article  CAS  Google Scholar 

  16. Faaborg-Anderson K. Electromyographic investigation of intrinsic laryngeal muscles in humans. Acta Physiol Scand. 1957;41.

  17. Belafsky PC, Postma GN, Whang C, Rees CJ, In MRAM. Diag nostic l aryngea l electromyography : the Wake Forest. Otolaryngol Head Neck Surg. 2001;124:603–6.

    PubMed  Google Scholar 

  18. • Ongkasuwan J, Espinosa MCL, Hollas S, Devore D, Procter T, Bassett E, et al. Predictors of voice outcome in pediatric non-selective laryngeal reinnervation. Laryngoscope. 2020;130:1525–31 This large cohort study (n=21) compared subjective and objective voice measures pre- and postoperative non-selective laryngeal reinnervation surgery. Ongkasuwan et al. found preoperative laryngeal electomyography can help predict voice outcomes after reinnervation with greater response in patients with electrical silence preoperatively.

    Article  Google Scholar 

  19. Smith ME, Houtz DR. Outcomes of laryngeal reinnervation for unilateral vocal fold paralysis in children: associations with age and time since injury. Ann Otol Rhinol Laryngol. 2016;125:433–8.

    Article  Google Scholar 

  20. • Caloway CL, Diercks GR, Randolph G, Hartnick CJ. Vagal stimulation and laryngeal electromyography for recurrent laryngeal reinnervation in children. Laryngoscope. 2020;130:747–51 This study presents three cases using intraoperative evoked vagal electromyography to determine recurrent laryngeal nerve status and predict intraoperative non-selective laryngeal reinnervation candidacy.

    Article  Google Scholar 

  21. Misono S, Merati AL. Evidence-Based Practice. Evaluation and management of unilateral vocal fold paralysis. Otolaryngol Clin N Am. 2012;45:1083–108.

    Article  Google Scholar 

  22. Sulica L. The natural history of idiopathic unilateral vocal fold paralysis: evidence and problems. Laryngoscope. 2008;118:1303–7.

    Article  Google Scholar 

  23. Jabbour J, North LM, Bougie D, Robey T. Vocal fold immobility due to birth trauma: a systematic review and pooled analysis. Otolaryngol - Head Neck Surg (U S). 2017;157:948–54.

    Article  Google Scholar 

  24. Alghonaim Y, Roskies M, Kost K, Young J. Evaluating the timing of injection laryngoplasty for vocal fold paralysis in an attempt To avoid future type 1 thyroplasty. J Otolaryngol Head Neck Surg. 2013;42:1.

    Article  Google Scholar 

  25. Dominguez LM, Tibbetts KM, Simpson CB. Inflammatory reaction to hyaluronic acid: a newly described complication in vocal fold augmentation. Laryngoscope. 2017;127:445–9.

    Article  CAS  Google Scholar 

  26. Friedman AD, Burns JA, Heaton JT, Zeitels SM. Early versus late injection medialization for unilateral vocal cord paralysis. Laryngoscope. 2010;120:2042–6.

    Article  Google Scholar 

  27. Yung KC, Likhterov I, Courey MS. Effect of temporary vocal fold injection medialization on the rate of permanent medialization laryngoplasty in unilateral vocal fold paralysis patients. Laryngoscope. 2011;121:2191–4.

    Article  Google Scholar 

  28. Ing C, DiMaggio C, Whitehouse A, Hegarty MK, Brady J, Von Ungern-Sternberg BS, et al. Long-term differences in language and cognitive function after childhood exposure to anesthesia. Pediatrics. 2012;130:e476–85.

    Article  Google Scholar 

  29. Sipp JA, Kerschner JE, Braune N, Hartnick CJ. Vocal fold medialization in children. Arch Otolaryngol Neck Surg. 2007.

  30. Frazier CH. The treatment of paralysis of the recurrent laryngeal nerve by nerve anastomosis. Ann Surg. 1924;79:161–71.

    Article  CAS  Google Scholar 

  31. Aynehchi BB, McCoul ED, Sundaram K. Systematic review of laryngeal reinnervation techniques. Otolaryngol Head Neck Surg. Elsevier Inc.;. 2010;143:749–59. https://doi.org/10.1016/j.otohns.2010.09.031.

    Article  PubMed  Google Scholar 

  32. Zur KB, Carroll LM. Recurrent laryngeal nerve reinnervation in children: acoustic and endoscopic characteristics pre-intervention and post-intervention. A comparison of treatment options. Laryngoscope. 2015;125:S1–15.

    Article  Google Scholar 

  33. Butskiy O, Mistry B, Chadha NK. Surgical interventions for pediatric unilateral vocal cord paralysis: a systematic review. JAMA Otolaryngol Head Neck Surg. 2015;141:654–60 Available from: http://archotol.jamanetwork.com/article.aspx?doi=10.1001/jamaoto.2015.0680/, http://www.ncbi.nlm.nih.gov/pubmed/25973887.

    Article  Google Scholar 

  34. Smith ME, Roy N, Houtz D. Laryngeal reinnervation for paralytic dysphonia in children younger than 10 years. Arch Otolaryngol Head Neck Surg. 2012;138:1161–6.

    Article  Google Scholar 

  35. Zur KB, Carroll LM. Recurrent laryngeal nerve reinnervation for management of aspiration in a subset of children. Int J Pediatr Otorhinolaryngol. Elsevier;. 2018;104:104–7. https://doi.org/10.1016/j.ijporl.2017.11.002.

    Article  PubMed  Google Scholar 

  36. Smith ME, Roy N, Stoddard K. Ansa-RLN reinnervation for unilateral vocal fold paralysis in adolescents and young adults. Int J Pediatr Otorhinolaryngol. 2008;72:1311–6.

    Article  Google Scholar 

  37. Bouhabel S, Hartnick CJ. Current trends in practices in the treatment of pediatric unilateral vocal fold immobility: a survey on injections, thyroplasty and nerve reinnervation. Int J Pediatr Otorhinolaryngol. Elsevier;. 2018;109:115–8. https://doi.org/10.1016/j.ijporl.2018.03.027.

    Article  PubMed  Google Scholar 

  38. Caloway CL, Bouhabel S, Hartnick CJ. Lessons learned to aid the successful outcome of pediatric recurrent laryngeal nerve reinnervation. Int J Pediatr Otorhinolaryngol. Elsevier;. 2020;128:109742. https://doi.org/10.1016/j.ijporl.2019.109742.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Julina Ongkasuwan.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical collection on LARYNGOLOGY: Management of Vocal Cord Paralysis

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Espinosa, M., Ongkasuwan, J. Pediatric Unilateral Vocal Fold Paralysis: Workup and Management. Curr Otorhinolaryngol Rep 9, 122–126 (2021). https://doi.org/10.1007/s40136-021-00335-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40136-021-00335-9

Keywords

Navigation