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Applying polyvinyl alcohol to the preparation of various nanoparticles

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Abstract

Background

Providing nanoscale monodisperse particles in nanoparticle-based drug delivery systems (DDSs) is an important issue in particle synthesis. To prepare uniform, controlled nanoparticles, the addition of stabilizer to the preparing process may be considered. Polyvinyl alcohol (PVA) is a suitable nonionic stabilizer in the body, providing stable colloidal dispersion through stereostatic stabilization.

Area covered

In this paper, the characteristics and role of PVA used as a stabilizer in the preparation of various nanoparticles, such as polymer nanoparticles, metal nanoparticles, and lipid nanoparticles, were reviewed. In addition, the prospect of nanoparticle-based DDSs containing PVA was discussed through studies related to in vivo safety.

Expert opinion

The information provided in this paper will aid in the preparation of nanoparticles using PVA, as this review summarizes the molar mass, degree of hydrolysis, and concentration of PVA used for colloidal stabilization. It also describes the nanoscale particle size and experimental results obtained by the application of PVA.

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This work was supported by the Basic Science Research Program (2019R1A2C10786102) through the National Research Foundation of Korea (NRF).

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  1. College of Pharmacy, Chungnam National University, 99, Daehak-ro, Daejeon, 31434, South Korea

    Bomin Song & Cheong-Weon Cho

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Song, B., Cho, CW. Applying polyvinyl alcohol to the preparation of various nanoparticles. J. Pharm. Investig. 54, 249–266 (2024). https://doi.org/10.1007/s40005-023-00649-4

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