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Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug

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Tissue Engineering and Regenerative Medicine Aims and scope

Abstract

A material for ridge preservation should have dimensional stability to resist bio-degradation. This study was designed to compare bio-degradation of ridge preservation materials. Collagen plug was used as a positive control. Untreated, ethanol-treated, and 4-hexylresorcinol (4HR)-treated silk plugs were used for the experimental group. Each material underwent a scanning electron microscopic exam and a Fourier transform infrared (FT-IR) spectroscopic exam. Bio-degradation was evaluated by analyzing cylindrical bony defects in rabbit tibias. There were no prominent differences in microstructure among the silk plug groups. FT-IR exam demonstrated that the ethanol- and 4HR-treated silk plug groups had enhanced β-sheet structure. All silk plug groups exhibited significantly higher residual graft than the collagen plug group 4 weeks postoperative (p < 0.05). In conclusion, silk fibroin-based ridge preservation material was less bio-degradable than a collagen plug until at least 4 weeks after grafting.

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Acknowledgements

This work was carried out with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ01121404)" Rural Development Administration, Republic of Korea.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju, 28644, Republic of Korea

    Hyun Seok

  2. Sericultural and Apicultural Materials Division, National Academy of Agricultural Science, Wanju-gun, 55365, Republic of Korea

    You-Young Jo & HaeYong Kweon

  3. Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, Gangneung, Gangwondo, 25457, Republic of Korea

    Seong-Gon Kim & Min-Keun Kim

  4. Daegu Center, Korea Basic Science Institute, Daegu, 41566, Republic of Korea

    Weon-Sik Chae

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  1. Hyun Seok
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  4. Seong-Gon Kim
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Correspondence to Seong-Gon Kim.

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Ethical statement

This animal experiment was approved by the Institutional Animal Care and Use Committee of the Gangneung-Wonju National University (GWNU-2016-23).

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Seok, H., Jo, YY., Kweon, H. et al. Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug. Tissue Eng Regen Med 14, 221–231 (2017). https://doi.org/10.1007/s13770-017-0055-0

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  • DOI: https://doi.org/10.1007/s13770-017-0055-0

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