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Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

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Abstract

Heterocyclization of furan-2-carbonyl isothiocyanate 1 with a variety of aliphatic and aromatic nitrogen nucleophiles resulted in the formation of a new series of heterocycles including triazines, pyrimidines, oxadiazines, imidazolidines, thiadiazoles and their condensed candidates. The antibacterial screening for a group of the newly synthesized compounds showed that they possess moderate antibacterial activities against examples of Gram-positive and Gram-negative bacteria.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

    Atef M. Abdel Hamid

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  1. Atef M. Abdel Hamid
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Abdel Hamid, A.M. Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity. J IRAN CHEM SOC 16, 1853–1861 (2019). https://doi.org/10.1007/s13738-019-01659-6

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  • DOI: https://doi.org/10.1007/s13738-019-01659-6

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