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Butyrate: More Than a Short Chain Fatty Acid

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Abstract

Purpose of Review

The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application.

Recent Findings

Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition.

Summary

Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, 200 1st St. SW, Rochester, MN, 55905, USA

    Osman Mohamed Elfadil, Manpreet S. Mundi, Marwa G. Abdelmagid, Ankitaben Patel & Nishant Patel

  2. Division of Gastrointestinal and General Surgery, School of Medicine, Oregon Health and Sciences University, Portland, OR, USA

    Robert Martindale

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  1. Osman Mohamed Elfadil
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Correspondence to Osman Mohamed Elfadil.

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Osman Mohamed Elfadil, Manpreet S. Mundi, Ankitaben Patel, Marwa G. Abdelmagid, Nishant Patel, and Robert Martindale have no conflicts of interest in relation to this manuscript to declare.

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Mohamed Elfadil, O., Mundi, M.S., Abdelmagid, M.G. et al. Butyrate: More Than a Short Chain Fatty Acid. Curr Nutr Rep 12, 255–262 (2023). https://doi.org/10.1007/s13668-023-00461-4

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