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Relationship between nonalcoholic fatty liver disease and bone mineral density in type 2 diabetic patients

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Purpose

To analyze the relationships between nonalcoholic fatty liver disease (NAFLD) and bone mineral density (BMD) in type 2 diabetes (T2DM) patients.

Methods

A total of 446 men aged ≥ 50 years and 306 postmenopausal women with T2DM were recruited. The differences of BMD levels in T2DM patients with or without NAFLD were analyzed. According to the tertile levels of BMD, T2DM patients with NAFLD were divided into three groups (T1, T2, and T3), and the differences in the prevalence of NAFLD were compared among the three groups. The independent influencing factors of NAFLD were analyzed.

Results

The right calcaneus and left forearm BMD levels of male and postmenopausal female T2DM patients with NAFLD were lower than those without NAFLD. After grouping according to the tertile levels of BMD of the right calcaneus, the prevalence of NAFLD in the T1 group (56.8%) was higher than that in the T2 or T3 group (42.6% or 40.7%) among male T2DM patients, and the prevalence of NAFLD in the T1 group was higher than that in the T3 group (77.2% vs.53.5%) among postmenopausal female T2DM patients. NAFLD was negatively associated with the right calcaneus and the left forearm BMD, and the right calcaneus BMD was an independent protective factor for NAFLD in male and postmenopausal female T2DM patients (OR = 0.014 and 0.006, p < 0.05).

Conclusion

For males aged ≥ 50 years or postmenopausal female T2DM patients with NAFLD, the BMD levels were lower, and lower BMD levels were more likely to lead to the development of NAFLD. The BMD was an independent protective factor for T2DM patients.

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Data availability

The data of this study is not publicly available due to data protection by the First Hospital of Lanzhou University. However, these are available from the corresponding author on reasonable request.

Code availability

All data were analyzed by IBM SPSS23.0 software.

Abbreviations

T2DM:

Type 2 diabetes mellitus

NAFLD:

Nonalcoholic fatty liver disease

BMD:

Bone mineral density

FPG:

Fasting blood glucose

HbA1c:

Glycosylated hemoglobin

TC:

Total cholesterol

TG:

Serum triglyceride

LDL-C:

Low-density lipoprotein cholesterol

HDL-C:

High-density lipoprotein cholesterol

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

UA:

Uric acid

BMI:

Body mass index

CA:

Calcium

P:

Phosphorus

25(OH)D:

25-Hydroxy vitamin D

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Funding

This study was funded by the National Natural Science Foundation of China (No. 81960155) and the health industry scientific research project of Gansu Province (No. GSWSKY-2019–07).

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Authors and Affiliations

  1. The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China

    Binjing Pan, Junxin Yan, Pingping Zhao, Jingfang Liu & Songbo Fu

  2. Department of Endocrinology, The First Hospital of Lanzhou University, 1 Donggang West Road, Lanzhou, Gansu, 730000, People’s Republic of China

    Jingfang Liu & Songbo Fu

Authors
  1. Binjing Pan
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  2. Junxin Yan
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  3. Pingping Zhao
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  4. Jingfang Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Miss Binjing Pan, Miss Junxin Yan, and Mr. Pingping Zhao. The first draft of the manuscript was written by Miss Binjing Pan and Dr. Jingfang Liu. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jingfang Liu.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Written and oral information of the protocol was explained to them before screening, and informed consent was obtained from each eligible participant.

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Not applicable.

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The authors declare no competing interests.

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Pan, B., Yan, J., Zhao, P. et al. Relationship between nonalcoholic fatty liver disease and bone mineral density in type 2 diabetic patients. Int J Diabetes Dev Ctries 42, 765–774 (2022). https://doi.org/10.1007/s13410-021-01022-7

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  • DOI: https://doi.org/10.1007/s13410-021-01022-7

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