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Ocular surface assessment in maturity-onset diabetes of the young

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Abstract

Aim

To examine ocular surface changes in patients with maturity-onset diabetes of young (MODY).

Material and methods

Fifty patients with MODY who were transferred to Genetic Diagnosis Department of Diskapi Yildirim Beyazit Training and Research Hospital have been included. All patients were subjected to Ocular Surface Illness Index (OSDI) survey, shirmer test, invasive and non-invasive tear break up time (TBUT), cornea fluorescein, and Lissamine green dye tests. Lastly, meibography measurements have been completed using Sirius Scheimpflug camera (Sirius, CSO, Florence, Italy).

Results

All 50 patients had a glucokinase (GCK) mutation. MODY diagnosis time was 5.0 ± 5.5 years (range: 0–20 years) on an average. While the average HBa1c levels were 5.5 (range: 4.8–6.5, reference range: 4–6), none of the patients were diagnosed with diabetic retinopathy in fundus examination. There was no significant difference between MODY and control group in terms of OSDI score, Schirmer 1 test, meibomian gland loss, average BUT, TBUT ((p)0.05).

Discussion

Our work is the first one which specifically evaluates ocular surface in MODY patients. Contrary to the common concept that “dry eye is frequently seen in type 1 and type 2 DM,” we did not come across any significant difference between MODY and control group in ocular surface tests. It might be linked to the fact that not enough time had passed for DR or DES symptoms to be detected. Our patients’ average diabetes diagnosis length might be a short time span for clinical symptoms like DR and DES to show up.

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References

  1. Caffery BE, Richter D, Simpson T, Fonn D, Doughty M, Gordon K. The Canadian dry eye epidemiology study. Adv Exp Med Biol. 1998;438:805–6.

    Article  CAS  Google Scholar 

  2. Seifart U, Strempel I. The dry eye and diabetes mellitus. Ophthalmologe. 1994;91:235–9.

    CAS  PubMed  Google Scholar 

  3. Jin J, Chen LH, Liu XL, Jin GS, Lou SX, Fang FN. Tear film function in non insulin dependent diabetics. Zhonghua Yan Ke Za Zhi. 2003;39:10–3.

    PubMed  Google Scholar 

  4. Akinci A, Cetinkaya E, Aycan Z. Dry eye syndrome in diabetic children. Eur J Ophthalmol. 2007;17:873–8.

    Article  CAS  Google Scholar 

  5. Pajans SS. GED: a model for understanding the pathogeneses and natural history of type II diabetes. Horm Metab Res. 1987;19:591–9.

    Article  Google Scholar 

  6. Ledermann HM. Maturity-onset diabetes of the young (GED) at least ten times more common in Europe than previously assumed? Diabetologia. 1995;138:1482.

    Article  Google Scholar 

  7. Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease Index. Arch Ophthalmol. 2000;118:615–21.

    Article  CAS  Google Scholar 

  8. Miller KL, Walt JG, Mink DR, Satram-Hoang S, Wilson SE, Perry HD, et al. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010;128:94–101.

    Article  Google Scholar 

  9. Lemp MA. Report of the National Eye Institute/Industry workshop on clinical trials in dry eyes. CLAO J. 1995;21:221–32.

    CAS  PubMed  Google Scholar 

  10. Berntsen DA, Mitchell GL, Nichols JJ. Reliability of grading lissamine green conjunctival staining. Cornea. 2006;25:695–700.

    Article  Google Scholar 

  11. Van Bijsterveld OP. Diagnostic tests in the sicca syndromes. Arch Ophthalmol. 1969;82:10–4.

    Article  Google Scholar 

  12. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain- terminating inhibitors. Proc Natl Acad Sci. 1977;74:5463–7.

    Article  CAS  Google Scholar 

  13. ManaviatMR RM, Afkhami-Ardekani M, Shoja MR. Prevalence of dry eye syndrome and diabetic retinopathy in type 2 diabetic patients. BMC Ophthalmol. 2008;8:10.

    Article  Google Scholar 

  14. Goebbels M. Tear secretion and tear film function in insulin dependent diabetics. Br J Ophtalmol. 2000;84:19–21.

    Article  CAS  Google Scholar 

  15. Jain S. Dry eyes in diabetes. Diabetes Care. 1998;21:1364–82.

    Article  Google Scholar 

  16. Uyanik FY, Cetin EN, Yaylali V, Avunduk AM, Yildirim C. Diyabetik Hastalarda Oküler Yüzey Sağlığı ve Kuru Göz. Turkiye Klinikleri J Ophthalmol. 2011;20:204–11.

    Google Scholar 

  17. Matschinsky FM, Randle PJ. Evolution of the glucokinase glucose sensor paradigm for pancreatic beta cells. Diabetologia. 1993;36:1215–7.

    Article  CAS  Google Scholar 

  18. Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, et al. Familial hyperglycemia due to mutations in glucokinase: definition of a subtype of diabetes. N Engl J Med. 1993;328:697–702.

    Article  CAS  Google Scholar 

  19. Cerf ME. Transcription factors regulating beta-cell function. Eur J Endocrinol. 2006;155:671–9.

    Article  CAS  Google Scholar 

  20. Kapoor RR, Locke J, Colclough K, Wales J, Conn JJ, Hattersley AT, et al. Persistent hyperinsulinemic hypoglycaemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations. Diabetes. 2008;57:1659–63.

    Article  CAS  Google Scholar 

  21. Bellanné-Chantelot C, Chauveau D, Gautier JF, Dubois-Laforgue D, Clauin S, Beaufils S, et al. Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Ann Intern Med. 2004;140:510–7.

    Article  Google Scholar 

  22. Saito J, Enoki M, Hara M, Morishige N, Chikama T, Nishida T. Correlation of corneal sensation, but not of basal or reflex tear secretion, with the stage of diabetic retinopathy. Cornea. 2003;22:15–8.

    Article  Google Scholar 

  23. Ozdemir M, Ozdemir G, Buyukbese MA, Cetinkaya A. Diyabetes Mellitusta Gözyaşı Fonksiyonu ve Oküler Yüzey Değişiklikleri. Turk J Ophthalmol. 2004;33:291–4.

    Google Scholar 

  24. Kaiserman I, Kaiserman N, Nakar S, Vinker S. Dry eye in diabetic patients. Am J Ophthalmol. 2005;139:498–503.

    Article  Google Scholar 

  25. Klein R, Klein BE, Moss SE, Davis ME, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophtalmol. 1984;102:4527–32.

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

    Osman Celikay, Mustafa Kosker, Sinan Çalışkan & Canan Gurdal

  2. Department of Endocrinology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

    Erman Cakal

  3. Genetic Diagnostic Center, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

    Ferda Alparslan Pinarli

Authors
  1. Osman Celikay
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  2. Mustafa Kosker
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  3. Sinan Çalışkan
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  4. Erman Cakal
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  5. Ferda Alparslan Pinarli
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  6. Canan Gurdal
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Correspondence to Osman Celikay.

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Approval has been taken from the local ethics committee and research has been carried out in compliance with the Helsinki Declaration. All the patients have been informed about the research and their informed consent has been received.

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Celikay, O., Kosker, M., Çalışkan, S. et al. Ocular surface assessment in maturity-onset diabetes of the young. Int J Diabetes Dev Ctries 41, 136–140 (2021). https://doi.org/10.1007/s13410-020-00843-2

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  • DOI: https://doi.org/10.1007/s13410-020-00843-2

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