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Altered iron metabolism as a target for ferroptosis induction in head and neck cancer

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Abstract

Iron is a mineral micronutrient essential for survival and vital functions in many biological processes in living organisms. Iron plays a crucial role as a cofactor of iron-sulfur clusters in energy metabolism and biosynthesis by binding with enzymes and transferring electrons to targets. Iron can also impair cellular functions by damaging organelles and nucleic acids by producing free radicals from redox cycling. Iron-catalyzed reaction products can induce active-site mutations in tumorigenesis and cancer progression. However, the boosted pro-oxidant iron form may contribute to cytotoxicity by increasing soluble radicals and highly reactive oxygen species via the Fenton reaction. An increased redox-active labile iron pool is required for tumor growth and metastasis, but the increased cytotoxic lipid radicals also lead to regulated cell death, such as ferroptosis. Therefore, this may be a major target for selectively killing cancer cells. This review intends to understand altered iron metabolism in cancers and discuss iron-related molecular regulators highly associated with iron-induced cytotoxic radical production and ferroptosis induction, focusing on head and neck cancer.

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Abbreviations

CISD1/2:

CDGSH iron-sulfur domain 1/2

Cys:

cysteine

Cys-Cys:

cystine

DMT1 (SLC11A2):

divalent metal (iron) transporter 1

FPN (SLC40A1):

ferroportin

FTH:

ferritin heavy chain

Glu:

glutamate

GPX4:

glutathione peroxidase 4

GRX5:

glutaredoxin 5

GSH:

glutathione

HAMP:

hepcidin

HO-1:

heme oxygenase 1

HNC:

head and neck cancer

Keap1:

Kelch-like ECH-associated protein 1

LIP:

labile iron pool

Mfr:

mitoferrin

NCOA4:

nuclear receptor coactivator 4

Nrf2:

nuclear erythroid 2-related factor

NTBI:

non-transferrin-bound-iron

PCBP:

poly(C)-binding protein

PL-PUFA:

polyunsaturated fatty acid-containing phospholipid

PL-PUFA-OH:

polyunsaturated fatty acid-containing phospholipid alcohol

STEAP3:

six-transmembrane epithelial antigen of prostate 3

TfR:

transferrin receptor

xCT (SLC7A11):

system xc– cystine/glutamate antiporter

References

  1. S.V. Torti, F.M. Torti, Mol. Aspects Med. 75, 100860 (2020). https://doi.org/10.1016/j.mam.2020.100860

  2. D.M. Ward, S.M. Cloonan, Annu. Rev. Physiol. 81, 453–482 (2019). https://doi.org/10.1146/annurev-physiol-020518-114742

    Article  CAS  PubMed  Google Scholar 

  3. A.R. Bogdan, M. Miyazawa, K. Hashimoto, Y. Tsuji, Trends Biochem. Sci 41, 274–286 (2016). https://doi.org/10.1016/j.tibs.2015.11.012

    Article  CAS  PubMed  Google Scholar 

  4. C. Zhang, F. Zhang, Protein & Cell 6, 88–100 (2015). https://doi.org/10.1007/s13238-014-0119-z

    Article  CAS  Google Scholar 

  5. R.A.M. Brown, K.L. Richardson, T.D. Kabir, D. Trinder, R. Ganss, P.J. Leedman, Front. Oncol. 10, 476 (2020). https://doi.org/10.3389/fonc.2020.00476

    Article  PubMed Central  PubMed  Google Scholar 

  6. D. Galaris, A. Barbouti, K. Pantopoulos, Biochim. Biophys. Acta. Mol. Cell Res. 1866, 118535 (2019). https://doi.org/10.1016/j.bbamcr.2019.118535

    Article  CAS  Google Scholar 

  7. J.J. Chen, L. Galluzzi, Trends Cell Biol. 28, 77–78 (2018). https://doi.org/10.1016/j.tcb.2017.11.007

    Article  CAS  PubMed  Google Scholar 

  8. B.R. Stockwell, J.P. Friedmann Angeli, H. Bayir, A.I. Bush, M. Conrad, S.J. Dixon, S. Fulda, S. Gascón, S.K. Hatzios, V.E. Kagan, K. Noel, X. Jiang, A. Linkermann, M.E. Murphy, M. Overholtzer, A. Oyagi, G.C. Pagnussat, J. Park, Q. Ran, C.S. Rosenfeld, K. Salnikow, D. Tang, F.M. Torti, S.V. Torti, S. Toyokuni, K.A. Woerpel, D.D. Zhang, Cell 171, 273–285 (2017). https://doi.org/10.1016/j.cell.2017.09.021

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. H. Feng, B.R. Stockwell, PLoS Biol. 16, e2006203 (2018). https://doi.org/10.1371/journal.pbio.2006203

  10. S.J. Dixon, K.M. Lemberg, M.R. Lamprecht, R. Skouta, E.M. Zaitsev, C.E. Gleason, D.N. Patel, A.J. Bauer, A.M. Cantley, W.S. Yang, B. Morrison, 3rd and B.R. Stockwell, Cell 149, 1060–1072 (2012). https://doi.org/10.1016/j.cell.2012.03.042

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. J. Hooda, A. Shah, L. Zhang, Nutrients 6, 1080–1102 (2014). https://doi.org/10.3390/nu6031080

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. D.J. Lane, D.H. Bae, A.M. Merlot, S. Sahni, D.R. Richardson, Nutrients 7, 2274–2296 (2015). https://doi.org/10.3390/nu7042274

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. E. Nemeth, T. Ganz, Int. J. Mol. Sci 22, (2021) https://doi.org/10.3390/ijms22126493

  14. G. Bao, M. Clifton, T.M. Hoette, K. Mori, S.X. Deng, A. Qiu, M. Viltard, D. Williams, N. Paragas, T. Leete, R. Kulkarni, X. Li, B. Lee, A. Kalandadze, A.J. Ratner, J.C. Pizarro, K.M. Schmidt-Ott, D.W. Landry, K.N. Raymond, R.K. Strong, J. Barasch, Nat. Chem. Biol 6, 602–609 (2010). https://doi.org/10.1038/nchembio.402

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. J.T. Busher, in Clinical Methods: The History, Physical, and Laboratory Examinations, ed. by H.K. Walker, W.D. Hall and J.W. Hurst (Butterworths 1990), pp. 497–499

  16. B. Angoro, M. Motshakeri, C. Hemmaway, D. Svirskis, M. Sharma, Clin. Chim. Acta 531, 157–167 (2022). https://doi.org/10.1016/j.cca.2022.04.004

    Article  CAS  PubMed  Google Scholar 

  17. Z.I. Cabantchik, Front. Pharmacol. 5, 45 (2014). https://doi.org/10.3389/fphar.2014.00045

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. B.P. Esposito, W. Breuer, P. Sirankapracha, P. Pootrakul, C. Hershko, Z.I. Cabantchik, Blood 102, 2670–2677 (2003). https://doi.org/10.1182/blood-2003-03-0807

    Article  CAS  PubMed  Google Scholar 

  19. E. Gammella, P. Buratti, G. Cairo, S. Recalcati, Metallomics: Integr. Biometal Sci. 9, 1367–1375 (2017). https://doi.org/10.1039/c7mt00143f

    Article  CAS  Google Scholar 

  20. M. Tabuchi, T. Yoshimori, K. Yamaguchi, T. Yoshida, F. Kishi, J. Biol. Chem 275, 22220–22228 (2000). https://doi.org/10.1074/jbc.M001478200

    Article  CAS  PubMed  Google Scholar 

  21. E.L. MacKenzie, K. Iwasaki, Y. Tsuji, Antioxid. Redox. Signal 10, 997–1030 (2008). https://doi.org/10.1089/ars.2007.1893

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. S. Colucci, O. Marques, S. Altamura, Semin. Hematol 58, 132–144 (2021). https://doi.org/10.1053/j.seminhematol.2021.05.001

    Article  PubMed  Google Scholar 

  23. R. Evstatiev, C. Gasche, Gut 61, 933–952 (2012). https://doi.org/10.1136/gut.2010.214312

    Article  CAS  PubMed  Google Scholar 

  24. E. Nemeth, T. Ganz, Hemat. Oncol. Clin. North Am. 28, 671–681, vi (2014). https://doi.org/10.1016/j.hoc.2014.04.005

  25. S.V. Torti, D.H. Manz, B.T. Paul, N. Blanchette-Farra, F.M. Torti, Annu. Rev. Nutr. 38, 97–125 (2018). https://doi.org/10.1146/annurev-nutr-082117-051732

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. D.L. Schonberg, T.E. Miller, Q. Wu, W.A. Flavahan, N.K. Das, J.S. Hale, C.G. Hubert, S.C. Mack, A.M. Jarrar, R.T. Karl, A.M. Rosager, A.M. Nixon, P.J. Tesar, P. Hamerlik, B.W. Kristensen, C. Horbinski, J.R. Connor, P.L. Fox, J.D. Lathia, J.N. Rich, Cancer cell. 28, 441–455 (2015). https://doi.org/10.1016/j.ccell.2015.09.002

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. X. Leng, Y. Wu, R.B. Arlinghaus, J. Cell. Physiol 226, 309–314 (2011). https://doi.org/10.1002/jcp.22403

    Article  CAS  PubMed  Google Scholar 

  28. Y. Chen, Z. Fan, Y. Yang, C. Gu, Int. J. Oncol 54, 1143–1154 (2019). https://doi.org/10.3892/ijo.2019.4720

    Article  CAS  PubMed  Google Scholar 

  29. Y. Aye, M. Li, M.J. Long, R.S. Weiss, Oncogene 34, 2011–2021 (2015). https://doi.org/10.1038/onc.2014.155

    Article  CAS  PubMed  Google Scholar 

  30. R. Kaomongkolgit, P. Cheepsunthorn, P. Pavasant, N. Sanchavanakit, Oral Oncol. 44, 587–594 (2008). https://doi.org/10.1016/j.oraloncology.2007.08.005

    Article  CAS  PubMed  Google Scholar 

  31. N. Tanaka, K. Sugihara, T. Odajima, M. Mimura, Y. Kimijima, S. Ichinose, Med. Electron. Microsc. 35, 127–138 (2002). https://doi.org/10.1007/s007950200016

    Article  CAS  Google Scholar 

  32. G. Magro, I. Cataldo, P. Amico, A. Torrisi, G.M. Vecchio, R. Parenti, S. Asioli, D. Recupero, V. D’Agata, M.T. Mucignat, R. Perris, Thyroid 21, 267–277 (2011). https://doi.org/10.1089/thy.2010.0173

    Article  CAS  PubMed  Google Scholar 

  33. J. Boult, K. Roberts, M.J. Brookes, S. Hughes, J.P. Bury, S.S. Cross, G.J. Anderson, R. Spychal, T. Iqbal, C. Tselepis, Clin. Cancer Res. 14, 379–387 (2008). https://doi.org/10.1158/1078-0432.ccr-07-1054

    Article  CAS  Google Scholar 

  34. M. Lenarduzzi, A.B. Hui, S. Yue, E. Ito, W. Shi, J. Williams, J. Bruce, N. Sakemura-Nakatsugawa, W. Xu, A. Schimmer, F.F. Liu, PloS One 8, e74075 (2013). https://doi.org/10.1371/journal.pone.0074075

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  35. Z. Hu, L. Wang, Y. Han, F. Li, A. Zheng, Y. Xu, F. Wang, B. Xiao, C. Chen, Z. Tao, Oncol. Lett. 17, 314–322 (2019). https://doi.org/10.3892/ol.2018.9642

    Article  CAS  PubMed  Google Scholar 

  36. J. Huang, B. Wan, S. Li, G. Liu, Q. Pang, J. Wu, E. Bao, C. Sun, Y. Qin, K. Wang, F. Yang, Y. Wu, F. Zhang, B. Yang, Aging 13, 5674–5685 (2021). https://doi.org/10.18632/aging.202492

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. C.W. Lin, W.E. Yang, W.J. Lee, K.T. Hua, F.K. Hsieh, M. Hsiao, C.C. Chen, J.M. Chow, M.K. Chen, S.F. Yang, M.H. Chien, Carcinogenesis 37, 712–722 (2016). https://doi.org/10.1093/carcin/bgw050

    Article  CAS  PubMed  Google Scholar 

  38. O. Kakhlon, Z.I. Cabantchik, Free Radical Biol. Med. 33, 1037–1046 (2002). https://doi.org/10.1016/s0891-5849(02)01006-7

  39. C.C. Winterbourn, Toxicol. Lett. 82–83, 969–974 (1995). https://doi.org/10.1016/0378-4274(95)03532-x

  40. U. Abbasi, S. Abbina, A. Gill, V. Bhagat, J.N. Kizhakkedathu, Sci. Rep 11, 6008 (2021). https://doi.org/10.1038/s41598-021-85387-z

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  41. R. Lill, B. Hoffmann, S. Molik, A.J. Pierik, N. Rietzschel, O. Stehling, M.A. Uzarska, H. Webert, C. Wilbrecht, U. Mühlenhoff, Biochim. Biophys. Acta 1823, 1491–1508 (2012). https://doi.org/10.1016/j.bbamcr.2012.05.009

    Article  CAS  PubMed  Google Scholar 

  42. A. Terman, T. Kurz, Antioxid. Redox. Signal. 18, 888–898 (2013). https://doi.org/10.1089/ars.2012.4885

    Article  CAS  PubMed  Google Scholar 

  43. T. Kurz, A. Leake, T. Von Zglinicki, U.T. Brunk, Biochem. J. 378, 1039–1045 (2004). https://doi.org/10.1042/bj20031029

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  44. P. Arosio, S. Levi, Biochim. Biophys. Acta 1800, 783–792 (2010) https://doi.org/10.1016/j.bbagen.2010.02.005

  45. V. Venkataramani, Adv. Exp. Med. Biol. 1301, 25–40 (2021). https://doi.org/10.1007/978-3-030-62026-4_3

  46. G. Gao, N. Zhang, Y.Q. Wang, Q. Wu, P. Yu, Z.H. Shi, X.L. Duan, B.L. Zhao, W.S. Wu, Y.Z. Chang, Aging Dis. 8, 458–470 (2017). https://doi.org/10.14336/ad.2016.1108

    Article  PubMed Central  PubMed  Google Scholar 

  47. S. Chiang, Z. Kovacevic, S. Sahni, D.J. Lane, A.M. Merlot, D.S. Kalinowski, M.L. Huang, D.R. Richardson, Clinical Sci. (Lond.) 130, 853–870 (2016). https://doi.org/10.1042/cs20160072

  48. G. Kroemer, M. Jäättelä, Nat. Rev. Cancer 5, 886–897 (2005). https://doi.org/10.1038/nrc1738

    Article  CAS  PubMed  Google Scholar 

  49. T. Kurz, J.W. Eaton, U.T. Brunk, Int. J. Biochem. Cell Biol 43, 1686–1697 (2011). https://doi.org/10.1016/j.biocel.2011.08.016

    Article  CAS  PubMed  Google Scholar 

  50. T. Asano, M. Komatsu, Y. Yamaguchi-Iwai, F. Ishikawa, N. Mizushima, K. Iwai, Mol. Cell. Biol 31, 2040–2052 (2011). https://doi.org/10.1128/mcb.01437-10

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  51. T. Kurz, B. Gustafsson, U.T. Brunk, Free Radic. Biol. Med 50, 1647–1658 (2011). https://doi.org/10.1016/j.freeradbiomed.2011.03.014

    Article  CAS  PubMed  Google Scholar 

  52. T. Kurz, B. Gustafsson, U.T. Brunk, FEBS J. 273, 3106–3117 (2006). https://doi.org/10.1111/j.1742-4658.2006.05321.x

    Article  CAS  PubMed  Google Scholar 

  53. J.D. Mancias, X. Wang, S.P. Gygi, J.W. Harper, A.C. Kimmelman, Nature 509, 105–109 (2014). https://doi.org/10.1038/nature13148

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  54. T.Z. Kidane, E. Sauble, M.C. Linder, American journal of physiology. Cell Physiol. 291, C445–C455 (2006). https://doi.org/10.1152/ajpcell.00505.2005

    Article  CAS  Google Scholar 

  55. C. Kishi-Itakura, I. Koyama-Honda, E. Itakura, N. Mizushima, J. Cell Sci 127, 4089–4102 (2014). https://doi.org/10.1242/jcs.156034

    Article  CAS  PubMed  Google Scholar 

  56. M.Q.D. Rey, J.D. Mancias, Front. NeuroSci 13, 238 (2019). https://doi.org/10.3389/fnins.2019.00238

    Article  Google Scholar 

  57. N. Santana-Codina, A. Gikandi, J.D. Mancias, Adv. Exp. Med. Biol 1301, 41–57 (2021). https://doi.org/10.1007/978-3-030-62026-4_4

    Article  CAS  PubMed  Google Scholar 

  58. M. Gao, P. Monian, Q. Pan, W. Zhang, J. Xiang, X. Jiang, Cell Res 26, 1021–1032 (2016). https://doi.org/10.1038/cr.2016.95

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  59. W. Hou, Y. Xie, X. Song, X. Sun, M.T. Lotze, H.J. Zeh 3rd, R. Kang, D. Tang, Autophagy 12, 1425–1428 (2016). https://doi.org/10.1080/15548627.2016.1187366

  60. K. Bersuker, J.M. Hendricks, Z. Li, L. Magtanong, B. Ford, P.H. Tang, M.A. Roberts, B. Tong, T.J. Maimone, R. Zoncu, M.C. Bassik, D.K. Nomura, S.J. Dixon, J.A. Olzmann, Nature 575, 688–692 (2019). https://doi.org/10.1038/s41586-019-1705-2

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. S. Doll, F.P. Freitas, R. Shah, M. Aldrovandi, M.C. da Silva, I. Ingold, A. Goya Grocin, T.N. Xavier da Silva, E. Panzilius, C.H. Scheel, A. Mourão, K. Buday, M. Sato, J. Wanninger, T. Vignane, V. Mohana, M. Rehberg, A. Flatley, A. Schepers, A. Kurz, D. White, M. Sauer, M. Sattler, E.W. Tate, W. Schmitz, A. Schulze, V. O’Donnell, B. Proneth, G.M. Popowicz, D.A. Pratt, J.P.F. Angeli, M. Conrad, Nature 575, 693–698 (2019). https://doi.org/10.1038/s41586-019-1707-0

  62. C. Mao, X. Liu, Y. Zhang, G. Lei, Y. Yan, H. Lee, P. Koppula, S. Wu, L. Zhuang, B. Fang, M.V. Poyurovsky, K. Olszewski, B. Gan, Nature 593, 586–590 (2021). https://doi.org/10.1038/s41586-021-03539-7

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  63. V.A.N. Kraft, C.T. Bezjian, S. Pfeiffer, L. Ringelstetter, C. Müller, F. Zandkarimi, J. Merl-Pham, X. Bao, N. Anastasov, J. Kössl, S. Brandner, J.D. Daniels, P. Schmitt-Kopplin, S.M. Hauck, B.R. Stockwell, K. Hadian, J.A. Schick, ACS Cent. Sci. 6, 41–53 (2020). https://doi.org/10.1021/acscentsci.9b01063

    Article  CAS  PubMed  Google Scholar 

  64. J.D. Mancias, L. Pontano Vaites, S. Nissim, D.E. Biancur, A.J. Kim, X. Wang, Y. Liu, W. Goessling, A.C. Kimmelman, J.W. Harper, eLife 4, (2015). https://doi.org/10.7554/eLife.10308

  65. A.A. Salahudeen, J.W. Thompson, J.C. Ruiz, H.W. Ma, L.N. Kinch, Q. Li, N.V. Grishin, R.K. Bruick, Science (New York, N.Y.) 326, 722–726 (2009). https://doi.org/10.1126/science.1176326

  66. Q. Guo, L. Li, S. Hou, Z. Yuan, C. Li, W. Zhang, L. Zheng, X. Li, Front. Oncol 11, 778492 (2021). https://doi.org/10.3389/fonc.2021.778492

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  67. A.A. Alkhateeb, J.R. Connor, Biochim. Biophys. Acta 1836, 245–254 (2013) https://doi.org/10.1016/j.bbcan.2013.07.002

  68. S.I. Shpyleva, V.P. Tryndyak, O. Kovalchuk, A. Starlard-Davenport, V.F. Chekhun, F.A. Beland, I.P. Pogribny, Breast Cancer Res. Treat 126, 63–71 (2011). https://doi.org/10.1007/s10549-010-0849-4

    Article  CAS  PubMed  Google Scholar 

  69. A.A. Waza, Z. Hamid, S. Ali, S.A. Bhat and M.A. Bhat, Inflamm. Res. 67, 579–588 (2018). https://doi.org/10.1007/s00011-018-1151-x

  70. S.K. Chiang, S.E. Chen, L.C. Chang, Int. J. Mol. Sci 20, (2018). https://doi.org/10.3390/ijms20010039

  71. M.Y. Ali, C.R. Oliva, S. Flor, P.C. Goswami, C.E. Griguer, Free Radic. Biol. Med 185, 25–35 (2022). https://doi.org/10.1016/j.freeradbiomed.2022.04.012

    Article  CAS  PubMed  Google Scholar 

  72. P. Gupta, P. Singh, H.S. Pandey, P. Seth, C.K. Mukhopadhyay, Biochim. Biophys. Acta. Gen. Subj. 1863, 547–564 (2019). https://doi.org/10.1016/j.bbagen.2018.12.013

    Article  CAS  Google Scholar 

  73. D. Tang, X. Chen, R. Kang, G. Kroemer, Cell Res. 31, 107–125 (2021). https://doi.org/10.1038/s41422-020-00441-1

    Article  CAS  PubMed  Google Scholar 

  74. A.J. Rennekamp, Cell 171, 1225–1227 (2017). https://doi.org/10.1016/j.cell.2017.11.029

    Article  CAS  PubMed  Google Scholar 

  75. B. Hassannia, P. Vandenabeele, T. Vanden Berghe, Cancer Cell. 35, 830–849 (2019). https://doi.org/10.1016/j.ccell.2019.04.002

    Article  CAS  PubMed  Google Scholar 

  76. D.J. Netz, J. Mascarenhas, O. Stehling, A.J. Pierik, R. Lill, Trends Cell Biol. 24, 303–312 (2014). https://doi.org/10.1016/j.tcb.2013.11.005

    Article  CAS  PubMed  Google Scholar 

  77. S.W. Alvarez, V.O. Sviderskiy, E.M. Terzi, T. Papagiannakopoulos, A.L. Moreira, S. Adams, D.M. Sabatini, K. Birsoy, R. Possemato, Nature 551, 639–643 (2017). https://doi.org/10.1038/nature24637

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  78. C.W. Brown, J.J. Amante, P. Chhoy, A.L. Elaimy, H. Liu, L.J. Zhu, C.E. Baer, S.J. Dixon, A.M. Mercurio, Dev. Cell 51, 575–586.e574 (2019). https://doi.org/10.1016/j.devcel.2019.10.007

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  79. A.L. Turcu, A. Versini, N. Khene, C. Gaillet, T. Cañeque, S. Müller, R. Rodriguez, Chemistry 26, 7369–7373 (2020). https://doi.org/10.1002/chem.202000159

    Article  CAS  Google Scholar 

  80. T.T. Mai, A. Hamaï, A. Hienzsch, T. Cañeque, S. Müller, J. Wicinski, O. Cabaud, C. Leroy, A. David, V. Acevedo, A. Ryo, C. Ginestier, D. Birnbaum, E. Charafe-Jauffret, P. Codogno, M. Mehrpour, R. Rodriguez, Nat. Chem. 9, 1025–1033 (2017). https://doi.org/10.1038/nchem.2778

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  81. A. Versini, L. Colombeau, A. Hienzsch, C. Gaillet, P. Retailleau, S. Debieu, S. Müller, T. Cañeque, R. Rodriguez, Chemistry 26, 7416–7424 (2020). https://doi.org/10.1002/chem.202000335

    Article  CAS  Google Scholar 

  82. A. Hamacher-Brady, H.A. Stein, S. Turschner, I. Toegel, R. Mora, N. Jennewein, T. Efferth, R. Eils, N.R. Brady, J. Biol. Chem 286, 6587–6601 (2011). https://doi.org/10.1074/jbc.M110.210047

    Article  CAS  PubMed  Google Scholar 

  83. N.D. Yang, S.H. Tan, S. Ng, Y. Shi, J. Zhou, K.S. Tan, W.S. Wong, H.M. Shen, J. Biol. Chem 289, 33425–33441 (2014). https://doi.org/10.1074/jbc.M114.564567

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  84. Q. Xiao, L. Yang, H. Hu, Y. Ke, J. Bioenerg. Biomembr. 52, 113–121 (2020). https://doi.org/10.1007/s10863-020-09823-x

    Article  CAS  PubMed  Google Scholar 

  85. J.L. Roh, E.H. Kim, H. Jang, D. Shin, Redox Biol. 11, 254–262 (2017). https://doi.org/10.1016/j.redox.2016.12.010

    Article  CAS  PubMed  Google Scholar 

  86. Y.F. Chen, C.H. Kao, R. Kirby, T.F. Tsai, Autophagy 5, 1043–1045 (2009). https://doi.org/10.4161/auto.5.7.9351

  87. E.H. Kim, D. Shin, J. Lee, A.R. Jung, J.L. Roh, Cancer Lett. 432, 180–190 (2018). https://doi.org/10.1016/j.canlet.2018.06.018

    Article  CAS  PubMed  Google Scholar 

  88. O. Karmi, S.H. Holt, L. Song, S. Tamir, Y. Luo, F. Bai, A. Adenwalla, M. Darash-Yahana, Y.S. Sohn, P.A. Jennings, R.K. Azad, J.N. Onuchic, F. Morcos, R. Nechushtai, R. Mittler, PloS One 12, e0175796 (2017). https://doi.org/10.1371/journal.pone.0175796

  89. Y.S. Sohn, S. Tamir, L. Song, D. Michaeli, I. Matouk, A.R. Conlan, Y. Harir, S.H. Holt, V. Shulaev, M.L. Paddock, A. Hochberg, I.Z. Cabanchick, J.N. Onuchic, P.A. Jennings, R. Nechushtai, R. Mittler, Proc. Natl. Acad. Sci. U.S.A 110, 14676–14681 (2013). https://doi.org/10.1073/pnas.1313198110

    Article  PubMed Central  PubMed  Google Scholar 

  90. H. Yuan, X. Li, X. Zhang, R. Kang, D. Tang, Biochem. Biophys. Res. Commun. 478, 838–844 (2016). https://doi.org/10.1016/j.bbrc.2016.08.034

    Article  CAS  PubMed  Google Scholar 

  91. S. Ciofi-Baffoni, V. Nasta, L. Banci, Metallomics 10, 49–72 (2018). https://doi.org/10.1039/c7mt00269f

    Article  CAS  Google Scholar 

  92. H. Ye, S.Y. Jeong, M.C. Ghosh, G. Kovtunovych, L. Silvestri, D. Ortillo, N. Uchida, J. Tisdale, C. Camaschella, T.A. Rouault, J. Clin. Investig. 120, 1749–1761 (2010). https://doi.org/10.1172/jci40372

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  93. G. Liu, Y. Wang, G.J. Anderson, C. Camaschella, Y. Chang, G. Nie, J. Cell. Biochem. 117, 207–217 (2016). https://doi.org/10.1002/jcb.25267

    Article  CAS  PubMed  Google Scholar 

  94. J. Lee, J.H. You, D. Shin, J.L. Roh, Theranostics 10, 7775–7786 (2020). https://doi.org/10.7150/thno.46903

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  95. H. Shi, K.Z. Bencze, T.L. Stemmler, C.C. Philpott, Science (New York, N.Y.) 320, 1207–1210 (2008). https://doi.org/10.1126/science.1157643

  96. S.J. Patel, O. Protchenko, M. Shakoury-Elizeh, E. Baratz, S. Jadhav, C.C. Philpott, Proc. Natl. Acad. Sci. U.S.A 118, (2021). https://doi.org/10.1073/pnas.2104666118

  97. W. Zhang, S. Zhang, W. Guan, Z. Huang, J. Kong, C. Huang, H. Wang, S. Yang, Front. Genet. 11, 930 (2020). https://doi.org/10.3389/fgene.2020.00930

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  98. J. Lee, J.H. You, J.L. Roh, Redox Biol. 51, 102276 (2022). https://doi.org/10.1016/j.redox.2022.102276

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  99. X. He, Q. Yao, D. Fan, L. Duan, Y. You, W. Liang, Z. Zhou, S. Teng, Z. Liang, D.D. Hall, L.S. Song, B. Chen, Life Sci. 277, 119457 (2021). https://doi.org/10.1016/j.lfs.2021.119457

    Article  CAS  PubMed  Google Scholar 

  100. H. Chen, Z. Li, J. Xu, N. Zhang, J. Chen, G. Wang, Y. Zhao, Oxid. Med. Cell Longev. 2023, 6896790 (2023). https://doi.org/10.1155/2023/6896790

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Acknowledgements

This study was supported by the National Research Foundation of Korea (NRF) grant, funded by the Ministry of Science and ICT (MSIT), Republic of Korea (No. 2019R1A2C2002259).

Funding

This study was supported by the National Research Foundation of Korea (NRF) grant, funded by the Ministry of Science and ICT (MSIT), Republic of Korea (No. 2019R1A2C2002259).

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Authors and Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, 13496, Seongnam, Gyeonggi-do, Republic of Korea

    Jaewang Lee & Jong-Lyel Roh

  2. Department of Biomedical Science, General Graduate School, CHA University, Seongnam, Republic of Korea

    Jaewang Lee & Jong-Lyel Roh

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  1. Jaewang Lee
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JL: Conceived the structure of the article and wrote the manuscript; JLR: Contributed to planning and manuscript writing, and acquired funding.

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Lee, J., Roh, JL. Altered iron metabolism as a target for ferroptosis induction in head and neck cancer. Cell Oncol. 46, 801–810 (2023). https://doi.org/10.1007/s13402-023-00784-y

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