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Synthesis, characterization, and antibacterial activity of amino-functionalized microcrystalline cellulose derivatives from cotton fibers

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Abstract

This study aims to develop a green and efficient method for synthesizing antimicrobial amino-functionalized microcrystalline celluloses from cotton fibers. Microcrystalline cellulose was prepared by acid hydrolyzing of cellulose. Tosyl cellulose was synthesized by tosylation of cellulose in an eco-friendly medium using NaOH/urea and decyl glucoside surfactant with DSTs of 0.51. Three amino-functionalized cellulose derivatives were synthesized by nucleophilic substitution reaction of tosyl cellulose with 3-aminopropyltrimethoylsilane, ethylenediamine, and triethylenetetramine. The physicochemical properties of investigated celluloses were characterized by Fourier transform infrared spectroscopy, X-ray diffraction analysis, scanning electron microscopy, and thermogravimetric analysis-differential scanning calorimetry. Microcrystalline cellulose with high crystallinity index (81.90%) and crystalline size of 0.30 nm was isolated from cotton fibers. After the dissolution and chemical modification, the crystalline form of cellulose was transformed from cellulose I to amorphous cellulose II. The thermal degradation of aminated cellulose was around 260 °C. The amino cellulose exhibited high inhibition activity against S. aureus, P. aeruginosa, and E. coli with MIC values less than 5 mg mL–1. The chemical modification of surface cellulose could deliver antimicrobial cellulosic materials with potential applications for air and water treatments or as ingredients in the food, cosmetic, and pharmaceutical industries.

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Funding

This research is funded by the Graduate University of Science and Technology under grant number GUST.STS.ĐT2018-HH03.

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Authors and Affiliations

  1. Faculty of Environmental and Food Engineering, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

    Minh Huy Do

  2. Faculty of Chemistry, University of Science, Vietnam National University–Ho Chi Minh City, Ho Chi Minh City, Vietnam

    Khanh Van Thi Khuat, Phuong Thanh Huynh & Luu Nhat Tan Nguyen

  3. Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho, D7, Ho Chi Minh City, Vietnam

    Bich Hang Do, Phuoc Dien Pham, Hiep Dinh Nguyen, Hien Minh Nguyen & Ut Dong Thach

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  1. Minh Huy Do
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  2. Khanh Van Thi Khuat
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  4. Luu Nhat Tan Nguyen
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Contributions

Minh Huy Do: investigation and writing—orginal draft. Thi Khanh Van Khuat: writing—review and editing and supervison. Phuong Thanh Huynh: investigation. Luu Nhat Tan Nguyen: investigation. Bich Hang Do: investigation and writing—review and editing. Phuoc Dien Pham: validation and writing—review and editing. Dinh Hiep Nguyen: writing—review and editing. Hien Minh Nguyen: writing—review and editing. Ut Dong Thach: conceptualization, writing—orginal draft, methodology, and funding acquisition.

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Correspondence to Ut Dong Thach.

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Do, M.H., Van Thi Khuat, K., Huynh, P.T. et al. Synthesis, characterization, and antibacterial activity of amino-functionalized microcrystalline cellulose derivatives from cotton fibers. Biomass Conv. Bioref. 13, 10595–10603 (2023). https://doi.org/10.1007/s13399-022-02391-7

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