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Can fasting plasma glucose replace oral glucose-tolerance test for diagnosis of gestational diabetes mellitus?

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Abstract

Background and aims

Gestational diabetes mellitus (GDM) has high prevalence worldwide. This study aimed to evaluate the fasting plasma glucose (FPG) cutoffs at first prenatal visit and at 24–28th of gestational weeks to avoid obtaining full oral glucose-tolerance test (OGTT) in the diagnosis of GDM.

Methods

This study was a cross-sectional study conducted in Tehran, Iran during October 2016 and November 2017. All pregnant women reporting for the first routine prenatal visit before 20th week of gestational age were included in this study. Participants without overt diabetes mellitus at first prenatal visit, underwent OGTT at 24–28th of gestational weeks.

Results

Totally 952 pregnant women with mean age of 26.4 ± 14.1 years took part in this study. The prevalence of GDM was 12.7% (mostly diagnosed based on the FPG alone). FPG cutoffs 75 and 80 mg/dL at first prenatal visit and at 24–28th of gestational weeks can rule out the GDM with high sensitivity and negative predictive value, respectively. FPG cutoffs 85 and 90 mg/dL at first prenatal visit and at 24–28th of gestational weeks had high capacity, excellent specificity and positive predictive value in diagnosing GDM, respectively.

Conclusions

Performing only the FPG and considering FPG cutoffs 75 and 80 mg/dL at first prenatal visit and at 24–28th of gestational weeks can be a useful tool predicting the incidence of GDM, respectively, and had similar diagnostic power.

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Acknowledgements

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, School of Medicine, Islamic Azad University Tehran Faculty of Medicine, Tehran, Iran

    Sepideh Babaniamansour

  2. Department of Internal Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ehsan Aliniagerdroudbari

  3. Department of Obstetrics and Gynecology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Maryam Afrakhteh

  4. Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Farhad Hosseinpanah

  5. Department of Obstetrics and Gynecology, Gynecology Cancer Research Center, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Farah Farzaneh

  6. Department of Internal Medicine, Division of Endocrinology, Clinical Research Development Unit of Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, 7th Floor, Bldg. No. 2, Tehran, Iran

    Mahtab Niroomand

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  1. Sepideh Babaniamansour
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  2. Ehsan Aliniagerdroudbari
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  3. Maryam Afrakhteh
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by MN, FH, FF and MA. The first draft of the manuscript was written by SB and EA and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Mahtab Niroomand.

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Conflict of interest

The authors declare no conflict of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector.

Human right statement

All the procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation and with the Helsinki Declaration (seventh revision 2013). The implementation of the project was approved by the ethics committee of Shahid Beheshti University of Medical Sciences (Approval number: IR.SBMU.MCP.REC.1395.563) in 2016.

Informed consent

Informed consent for it was obtained from all patients for being included in the study.

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Babaniamansour, S., Aliniagerdroudbari, E., Afrakhteh, M. et al. Can fasting plasma glucose replace oral glucose-tolerance test for diagnosis of gestational diabetes mellitus?. Diabetol Int 12, 277–285 (2021). https://doi.org/10.1007/s13340-020-00484-0

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  • DOI: https://doi.org/10.1007/s13340-020-00484-0

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