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MOTHER Study: A Multicenter Observational, Retrospective Study to Determine Coorelation Between Physical CHaracteristics and Ovarian REserve Markers in Sub-feRtile Women

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Abstract

Background

The physical characteristics which are known to affect the ovarian reserve are age, body mass index (BMI), occupational exposures, age at menarche and menstrual cycle length. A correlation between different physical characteristics and the ovarian reserve will help to identify areas which need to be tackled to increase the chances of fertility of women in India.

Methods

In this retrospective, observational study, namely the MOTHER Study, data of women between 18 and 45 years of age, attending the selected fertility centers across different states in India were taken for evaluation. Demographic information along with information on factors potentially related to fertility like age of menarche, menstrual cycle length and occupational factors were collected by review of medical records at screening visit. Most recent AMH assay and antral follicle count (AFC) where the subject has not taken any contraceptives 12 months prior to the test were collected.

Results

Age of woman, years of marriage, years of infertility and smoking have shown effect on ovarian reserve testing like AMH and AFC. The other physical characteristics which were evaluated and considered to affect the ovarian reserve like body mass index BMI, occupational exposures, age at menarche and menstrual cycle length have not shown statistically significant correlation.

Conclusion

Age of woman and years of infertility are inversely proportional to ovarian reserve markers, namely AMH and AFC. Addictions like smoking and alcohol affect ovarian reserve.

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Acknowledgements

The Federation of Obstetric and Gynecological Society of India (FOGSI). Dr.Jaideep Malhotra, President, FOGSI 2018. Dr.Nandita Palshetkar, President, FOGSI 2019. Dr.Jaydeep Tank, Secretary General, FOGSI

Funding

The Federation of Obstetric and Gynecological Society of India (FOGSI).

Author information

Authors and Affiliations

  1. Parvathy Ayyavoo Fertility Centre, Aditi Hospital, 5, Usman Ali Street, TVS Tolgate, Trichy, Tamil Nadu, 620020, India

    Charmila Ayyavoo

  2. Disha Fertility and Surgical Centre, E-30, Saket Nagar, Indore, Madhya Pradesh, 452018, India

    Asha Baxi & Sonam Baxi

  3. Mandrupkar Clinic, More Nagar, Near ST Stand, Islampur (Dist- Sangli), Maharashtra, 415409, India

    Gorakh Mandrupkar

  4. Southend Fertility and IVF, Max Smart Super Speciality Hospital, Press Enclave Road, Malviya Nagar, Saket, New Delhi, 110017, India

    Sonia Malik

  5. Garbba Rakshambigai Fertility Center, Jayam Hospital, No. 4, 6th Cross Street, United India Colony, Kodambakkam, Chennai, Tamil Nadu, 600024, India

    Jayam Kannan

  6. Institute of Human Reproduction, Bharalumukh, Guwahati, Assam, 781009, India

    Deepak Goenka & Kanchan Murarka Agarwal

  7. Janani Hospital and IVF Centre, Gandhi Nagar, Tumkur, Karnataka, 572101, India

    Nagesh Kumar

  8. Bhopal Test-Tube-Baby and Endoscopy Centre, E-1/13A, Arera Colony, Near No. 7 Stop, Bhopal, Madhya Pradesh, 462016, India

    Monica Singh

  9. Siddhilife Assisted Reproduction Center, A Wing 101, First floor, Mrud Kishore Building Dattapada Phatak Road, Off S.V.Road, Borival West Mumbai, 40009, India

    Sharda Kulkarni

Authors
  1. Charmila Ayyavoo
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  2. Asha Baxi
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  3. Gorakh Mandrupkar
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  4. Sonia Malik
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  5. Jayam Kannan
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  6. Deepak Goenka
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  7. Nagesh Kumar
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  8. Monica Singh
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  9. Sharda Kulkarni
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  10. Kanchan Murarka Agarwal
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  11. Sonam Baxi
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Corresponding author

Correspondence to Charmila Ayyavoo.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

Royal Pune Independent Ethics Committee, India with CTRI number CTRI/2018/12/016772 and was registered on 21/12/2018.

Informed Consent

Informed consent was obtained from all individual participants involved in the study.

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Charmila Ayyavoo is the Director of Aditi Hospital and Parvathy Ayyavoo Fertility Centre in , Usman Ali Street, TVS Tolgate, Trichy-620020, Tamil Nadu, India. Asha Baxi is a MS, FRCOG, FICOG degree holder in Disha Fertility and Surgical Centre, E-30, Saket Nagar, Indore, Madhya Pradesh, 452018, India. Gorakh Mandrupkar is a MD in Mandrupkar Clinic, More Nagar, Near ST Stand, Islampur (Dist- Sangli), Maharashtra, 415409, India . Sonia Malik is a MD in Southend Fertility and IVF, Max Smart Super Speciality Hospital, Press Enclave Road, Malviya Nagar, Saket, New Delhi, 110017, India. Jayam Kannan is MD, DGO, FICOG in Garbba Rakshambigai Fertility Center, Jayam Hospital, No. 4, 6th Cross Street, United India Colony, Kodambakkam, Chennai, Tamil Nadu, 600024, India. Deepak Goenka is MD, FICOG, FIAOG in Institute of Human Reproduction, Bharalumukh, Guwahati, Assam, 781009, India. Nagesh Kumar is DGO in Janani Hospital and IVF Centre, Gandhi Nagar, Tumkur, Karnataka, 572101, India. Monica Singh is MD, DNB, FMAS, FICOG in Bhopal Test-tube-baby and Endoscopy Centre, E-1/13A, Arera Colony, Near No. 7 Stop, Bhopal, Madhya Pradesh, 462016, India. Sharda Kulkarni is MD, DGO, FRCOG in Siddhilife Assisted Reproduction Center, Borival West Mumbai, 40009, India. Kanchan Murarka Agarwal is DGO, FICOG, FIAOG in Institute of Human Reproduction, Bharalumukh, Guwahati, Assam, 781009, India. Sonam Baxi is MS in Disha Fertility and Surgical Centre, E-30, Saket Nagar, Indore, Madhya Pradesh, 452018, India.

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Ayyavoo, C., Baxi, A., Mandrupkar, G. et al. MOTHER Study: A Multicenter Observational, Retrospective Study to Determine Coorelation Between Physical CHaracteristics and Ovarian REserve Markers in Sub-feRtile Women. J Obstet Gynecol India 71, 510–521 (2021). https://doi.org/10.1007/s13224-020-01410-9

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  • DOI: https://doi.org/10.1007/s13224-020-01410-9

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