Abstract
Infertility affects 1 out of 6 couples of the world population and has multifactorial etiologies. The aim of the present study is to identify the correlation between some causative factors and female infertility. The detailed proforma with patient’s informed consent was filled out for total 120 females (42 control females and 78 case females, which included personal information, family history, lifestyle factors and serum hormone levels). Results showed that age, body mass index (BMI), previous history of miscarriage, and previous history of conception were significantly (p < 0.001) associated with female infertility. Similarly, independent t test results of clinical profile showed significant (p < 0.001) association of serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), progesterone, and anti-Mullerian hormone (AMH). There was a non-significant association of lifestyle factors (alcohol consumption, smoking, diet, caffeine consumption, and menstrual cycle regularity) and family history of consanguineous marriage with female infertility. Also, we have found a nonsignificant association between female infertility and complaint of infertility in other family members of probands. The present study confirms that these factors are important aspects for determining the etiology of female infertility and will further help in the management of disease and provide essential treatment if required.
Zusammenfassung
Unfruchtbarkeit betrifft 1 von 6 Paaren der Weltbevölkerung und hat multifaktorielle Ätiologien. Das Ziel der vorliegenden Studie ist es, die Korrelation zwischen einigen ursächlichen Faktoren und weiblicher Unfruchtbarkeit zu identifizieren. Ein detaillierter Fragebogen, inklusive Einverständniserklärung der Patientin, wurde von insgesamt 120 Frauen (42 Kontrollen und 78 betroffene Frauen) mit Angaben zur Person, Familienanamese, Lebensstilfaktoren und Serumhormonspiegeln ausgefüllt. Die Ergebnisse zeigten, dass Alter, Body-Mass-Index (BMI), Vorgeschichte von Fehlgeburt und Vorgeschichte der Empfängnis signifikant (p < 0,001) im Zusammenhang mit weiblicher Unfruchtbarkeit stehen. In ähnlicher Weise zeigten die unabhängigen t‑Test-Ergebnisse des klinischen Profils einen signifikanten (p < 0,001) Zusammenhang zwischen den Serumspiegeln von follikelstimulierendem Hormon (FSH), luteinisierendem Hormon (LH), Prolaktin (PRL), Progesteron und Anti-Müller-Hormon (AMH). Es gab keinen signifikanten Zusammenhang von Lebensstilfaktoren (wie Alkoholkonsum, Rauchen, Ernährung, Koffeinkonsum und Regelmäßigkeit des Menstruationszyklus) und Familienanamnese von Blutsverwandtschaft mit weiblicher Unfruchtbarkeit. Außerdem wurde ein nicht signifikanter Zusammenhang zwischen weiblicher Unfruchtbarkeit und Beschwerden über Unfruchtbarkeit bei anderen Familienmitgliedern der Probanden gefunden. Die vorliegende Studie bestätigt, dass diese Faktoren wichtige Aspekte für die Bestimmung der Ätiologie weiblicher Unfruchtbarkeit sind und bei der Behandlung der Krankheit weiterhelfen können, um bei Bedarf notwendige Behandlungen durchzuführen.
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Sanghavi, P., Savsaiya, B., Patel, H. et al. Factors Affecting Female Infertility in the Population of Gujarat (India): A Comprehensive Study. J. Gynäkol. Endokrinol. AT 33, 85–92 (2023). https://doi.org/10.1007/s41974-022-00240-z
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DOI: https://doi.org/10.1007/s41974-022-00240-z