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Experimental study on the therapeutic effect of BDNF gene-carrying nanoparticles on traumatic brain injury

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Abstract

In recent years, with the rapid development of medical biotechnology, gene therapy, an emerging technology, has been widely used clinically. At present, the main clinical treatment methods for craniocerebral trauma include surgery, drug therapy, hyperbaric oxygen, nutritional support, and mild hypothermia. The therapeutic effect, especially for severe craniocerebral injury, is often unsatisfactory. To understand the pathology of traumatic brain injury and the role of nanoparticles carrying BDNF gene in the diagnosis and treatment of patients with traumatic brain injury, this article collects relevant information by investigating patients and relevant literature, interviewing professionals, etc., constructing case templates, and using comprehensive quantitative and qualitative analysis methods to create a damage assessment matrix. The results of the study found that in patients, traumatic brain injuries are mostly caused by impact and fall injuries and are extremely harmful to human health. Nanoparticles carrying the BDNF gene can play a great role in the treatment of patients, which can greatly reduce the functional damage of patients, about 30% higher than general treatment methods. These can also play a certain role in the prognosis of rehabilitation and effectively prevent related postoperative complications. This shows that the BDNF gene-carrying nanoparticles should attract people’s attention in the diagnosis and treatment of patients with craniocerebral trauma. Research and development and promotion efforts need to be increased, so that the BDNF gene-carrying nanoparticles can play a greater role in the diagnosis and treatment of craniocerebral trauma patients.

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Authors and Affiliations

  1. Department of Neurosurgery, Heji Hospital Affiliated to Changzhi Medical College, No. 271 Taihang East Street, Luzhou District, Changzhi, 046011, Shanxi Province, China

    Shuangwei Shao, Tiezhu Guo, Fan Li, Zhiqiang Zhao, Jianhong Li & Xiangdong Wang

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  1. Shuangwei Shao
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  2. Tiezhu Guo
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  3. Fan Li
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  4. Zhiqiang Zhao
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  5. Jianhong Li
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  6. Xiangdong Wang
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Correspondence to Xiangdong Wang.

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The authors declare that they have no competing interests.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Shao, S., Guo, T., Li, F. et al. Experimental study on the therapeutic effect of BDNF gene-carrying nanoparticles on traumatic brain injury. Appl Nanosci 13, 3447–3458 (2023). https://doi.org/10.1007/s13204-022-02405-w

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  • DOI: https://doi.org/10.1007/s13204-022-02405-w

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