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Application of Nanozymes and its Progress in the Treatment of Ischemic Stroke

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Abstract

Nanozymes are a new kind of material which has been applied since the beginning of this century, and its birth has promoted the development of chemistry, materials science, and biology. Nanozymes can be used as a substitute for natural enzyme and has a wide range of applications; therefore, it has attracted extensive attention from all sectors of the community, and the number of studies has constantly increasing. In this paper, we introduced the outstanding achievements in the field of nanozymes in recent years from the main function, the construction of nanozyme-based biosensors, and the treatment of ischemic stroke, and we also illustrated the internal mechanism and the catalytic principle. In the end, the obstacles and challenges in the future development of nanozymes were proposed.

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Abbreviations

AchE:

acetylcholinesterase

ACP:

acid phosphatase

ALP:

alkaline phosphatase

BBB:

blood-brain barrier

C60 :

fullerene

CAT:

catalase

C-dots:

carbon nanodots

CEA:

carcinoembryonic antigen

ChI:

choline iodide

CL:

chemiluminescence

DA:

dopamine

Eda:

edaravone

GDYO:

graphdiyne oxide

GO-COOH:

carboxyl-modified graphene oxide

GOD:

glucose oxidase

GOQD:

graphene oxide quantum dot

GPx:

glutathione peroxidase

GQD:

graphene quantum dots

GSHOX:

glutathione oxidase

H2O2 :

hydrogen peroxide

HRP:

horseradish peroxidase

MOF:

metal-organic framework

NPs:

nanoparticles

OTA:

ochratoxin A

OXD:

oxidase

oxTMB:

oxidation TMB

pDA:

polydopamine

POD:

peroxidase

PTT:

photothermal therapy

RONs:

reactive nitrogen species

ROS:

reactive oxygen species

SERS:

surface-enhanced Raman scattering

SOD:

superoxide dismutase

TA:

terephthalic acid

TMB:

3,3’,5,5’-tetramethylbenzidine

UDG:

uracil DNA glycosylase

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Acknowledgements

This work was supported in part by grants of National Natural Science Foundation of China (No.81870938), Natural Science Foundation of Shandong Province (No.ZR2019ZD32, ZR2021QH160, ZR2022QH120, ZR2021MH025), Fund of Taishan Scholar Project, Fund of Teaching Promotion Programme, and Fund of Academic Promotion Program of Shandong First Medical University & Shandong Academy of Medical Sciences (No.2019QL016).

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Authors and Affiliations

  1. School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong, China

    Qing Han, Hongming Zhang & Baoliang Sun

  2. Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China

    Qing Han, Chengcheng Wang, Jian Liu, Cai Wang, Hongming Zhang, Ying Wang & Baoliang Sun

  3. Postdoctoral Workstation, Taian Central Hospital, Taian, 271000, Shandong, China

    Qingbin Ni

  4. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China

    Jingyi Sun

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Han, Q., Wang, C., Liu, J. et al. Application of Nanozymes and its Progress in the Treatment of Ischemic Stroke. Transl. Stroke Res. (2023). https://doi.org/10.1007/s12975-023-01182-0

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