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Neurophysiopathological Aspects of Paclitaxel-induced Peripheral Neuropathy

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Abstract

Chemotherapy is widely used as a primary treatment or adjuvant therapy for cancer. Anti-microtubule agents (such as paclitaxel and docetaxel) are used for treating many types of cancer, either alone or in combination. However, their use has negative consequences that restrict the treatment's ability to continue. The principal negative effect is the so-called chemotherapy-induced peripheral neuropathy (CIPN). CIPN is a complex ailment that depends on diversity in the mechanisms of action of the different chemotherapy drugs, which are not fully understood. In this paper, we review several neurophysiological and pathological characteristics, such as morphological changes, changes in ion channels, mitochondria and oxidative stress, cell death, changes in the immune response, and synaptic control, as well as the characteristics of neuropathic pain produced by paclitaxel.

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Abbreviations

AIDS:

Acquired Immunodeficiency Syndrome

ATF3:

Activating Transcription Factor 3

BMI:

Body Mass Index

BSA:

Body Surface Area

CGRP:

Calcitonin Gene-Related Peptide

CIPN:

Chemotherapy-induced peripheral neuropathy

CX3CL1:

Chemokine (C-X3-C motif) Ligand 1

DRG:

Dorsal root ganglion

EAAT:

Excitatory Amino Acid Transporter

EB3:

Ending Binding Protein 3

ERK:

Extracellular Signal-Regulated Kinase

GABA:

Gamma-aminobutyric acid

GFAP:

Glial fibrillary acidic protein

GM-CSF:

Granulocyte–macrophage colony-stimulating factor

GS:

Glutamine Synthase

HIF-I:

Hypoxia-inducible factor 1 signaling pathway

IL-10:

Interleukin 10

IL-12p70:

Interleukin 12, p70

IL-1β:

Interleukin 1-β

IL-6:

Interleukin 6

lncRNA:

Long noncoding RNA

MAPK:

Mitogen Activated Protein Kinase

MCP-1:

Monocyte chemoattractant protein 1

mPTP:

Mitochondrial Protein Transition Pore

mRNA:

Messenger RNA

Nav:

Voltage-gated sodium channel

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NSAID:

Non-Steroid Anti-inflammatory Drug

PAC:

Paclitaxel

P-APS:

Paclitaxel Indiced Acute Pain Syndrome

PAR2:

Tryptase-Activated Receptor 2

PIPN:

Paclitaxel-induced peripheral neuropathy

PKA:

Protein Kinase A

PKC:

Protein Kinase C

RVM:

Rostral Ventromedial Medulla

siRNA:

Small Interfering RNA

TLR4:

Toll-Like Receptor 4

TNF-α:

Tumor Necrosis Factor

TPH:

Tryptophan Hydroxylase

TRP:

Transient Receptor Potential

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Acknowledgements

The authors would like to thank the Universidad Nacional Autónoma de México (UNAM) and its postgraduate program in Biological Sciences for its support in the realization of this paper.

Funding

The present work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT) by providing R. Velasco-González (CVU 854822) with grant 778710.

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  1. Laboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Ciudad de México, México

    Roberto Velasco-González & Ulises Coffeen

  2. Maestría en Ciencias Biológicas, UNAM, Ciudad de México, México

    Roberto Velasco-González

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U.C. had the idea for the article, R.V.G performed the literature search and data analysis, and U.C. and R.V.G. drafted and critically revised the work.

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Correspondence to Ulises Coffeen.

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Velasco-González, R., Coffeen, U. Neurophysiopathological Aspects of Paclitaxel-induced Peripheral Neuropathy. Neurotox Res 40, 1673–1689 (2022). https://doi.org/10.1007/s12640-022-00582-8

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