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Plasma Inflammatory Biomarkers and Anorexia of Ageing among Community-Dwelling Older Adults: An Exploratory Analysis of the MAPT Study

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The journal of nutrition, health & aging

Abstract

Anorexia of aging and biological aging might share physiological underpinnings. The aim of this secondary analysis was to investigate the associations between circulating inflammation-related markers and anorexia of aging in community-dwelling older adults. C-reactive protein (CRP), tumor necrosis factor receptor-1 (TNFR-1), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and growth/differentiation factor-15 (GDF-15) were measured in plasma. Anorexia of aging was defined by the response “severe/moderate decrease in food intake” to the first item of the Mini-Nutritional Assessment. We included 463 subjects (median age=74y, IQR=71–78; 63.1% women). 33 subjects (7.1%) presented with anorexia at baseline, whereas 25 out of 363 (6.9%) developed it along 1-year follow-up. We found that TNFR1 (OR=1.74, 95%CI=1.27–2.39) and GDF-15 (OR=1.38, 95%CI=1.01–1.89) were associated with a significant increase in the odds of presenting with anorexia of aging cross-sectionally. No further significant associations were found. Biological aging mechanisms might be involved in the pathogenesis of anorexia of aging.

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Author information

Authors and Affiliations

  1. Department of Health Sciences, Public University of Navarre, Pamplona, Spain

    Juan Luis Sánchez-Sánchez

  2. Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France

    Juan Luis Sánchez-Sánchez, S. Guyonnet, Y. Rolland & P. de Souto Barreto

  3. Maintain Aging Research Team, CERPOP, Inserm, Université Paul Sabatier, Toulouse, France

    S. Guyonnet, Y. Rolland & P. de Souto Barreto

  4. Institute of Metabolic and Cardiovascular Diseases (I2MC), Inserm UMR 1297, University of Toulouse, Toulouse, France

    A. Lucas & A. Parini

  5. CHU Toulouse Gérontopôle: Centre Hospitalier Universitaire de Toulouse, Gerontopole, France

    Juan Luis Sánchez-Sánchez

Authors
  1. Juan Luis Sánchez-Sánchez
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  2. S. Guyonnet
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  3. A. Lucas
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  4. A. Parini
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  6. P. de Souto Barreto
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Correspondence to Juan Luis Sánchez-Sánchez.

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Ethical standards: This research complied with the ethical rules for human experimentation stated in the Declaration of Helsinki.

Conflict of interest: The authors declare the absence of conflicts of interest.

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Sánchez-Sánchez, J.L., Guyonnet, S., Lucas, A. et al. Plasma Inflammatory Biomarkers and Anorexia of Ageing among Community-Dwelling Older Adults: An Exploratory Analysis of the MAPT Study. J Nutr Health Aging 27, 1127–1131 (2023). https://doi.org/10.1007/s12603-023-2024-8

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  • DOI: https://doi.org/10.1007/s12603-023-2024-8

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