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Drug delivery with Mn-doped MoO2 for photothermal-enhanced chemotherapy in fighting cancers

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Abstract

Although chemotherapy has been intensively applied in cancer treatments, its inadequate therapeutic efficacy and severe side effects are still under constant concerns. Nanoplatforms used as anti-tumor drug delivery system (DDS) have attracted tremendous attentions owing to their various intriguing properties. Herein, Mn-doped MoO2 nanoparticles coated with ZrO2 and capped with Bi2O3 have been designed as a DDS, namely MMZB. MMZB possesses good magnetic properties, great photothermal conversion ability, sensitive tumor microenvironment (TME) responsiveness, and good biocompatibility in hemocompatibility in vitro. Thus, MMZB has been utilized to load the chemotherapeutic agent daunomycin (DNM) (MMZB@DNM) for chemo-photothermal combined therapy. MMZB@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in vivo. Furthermore, the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in vivo. This contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments, which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

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摘要

尽管化疗在癌症治疗中得到广泛的应用, 但其不理想的疗效和严重的副作用仍然备受关注。纳米平台作为抗肿瘤药物递送系统 (DDS), 由于其各种有趣的特性而引起了人们的极大关注。在此, 用ZrO2包裹并用Bi2O3封堵的Mn掺杂MoO2纳米颗粒被设计为DDS, 即MMZB。MMZB具有良好的磁性、良好的光热转换能力、敏感的肿瘤微环境反应性和良好的体外血液相容性。因此, MMZB被用于装载化疗剂柔红霉素 (DNM) (MMZB@DNM)用于化学-光热联合治疗。MMZB@DNM在体外和体内显示出比单独的光热或化学疗法更优异的抗癌效果。此外, 对肿瘤标本切片和治疗后血清水平的分析表明MMZB@DNM体内副作用很低。本工作将化疗和光热治疗组合在单一纳米体系, 为抗肿瘤药物研发提供了新的思路。

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Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (Nos. 22271178 and 22001156), Project of Special Key Fields in Guangdong Province (No. 2021ZDZX4019), the Science and technology innovation strategy of Guangdong province (No. 51361212), and Guangdong Provincial Science and Technology Innovation Strategy Special Fund Approval Project (No. pdjh2021b0266).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Ping Zhao, Hai-Fa Zheng, Ju Peng, Xing-Long Li, Xiao-Jun Liu & Hao-Quan Yu

  2. KAUST Catalysis Center, King Abdullah University of Science and Technology, 23955-6900, Thuwal, Kingdom of Saudi Arabia

    Fazal Raziq

  3. Key Laboratory of Chemical Additives for China National Light Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an, 710021, China

    Jin-Lu Tang, Yi-Fan Kang & Wen-Huan Huang

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Zhao, P., Zheng, HF., Peng, J. et al. Drug delivery with Mn-doped MoO2 for photothermal-enhanced chemotherapy in fighting cancers. Rare Met. 43, 2230–2240 (2024). https://doi.org/10.1007/s12598-023-02568-7

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