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Recent developments in nonferrous metals and related materials for biomedical applications in China: a review

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Abstract

Biomedical materials have received increasing attention in recent decades and have been used in medical applications to advance patient care, such as prosthetic implants, tissue repair and regeneration, drug delivery systems, pharmaceutical or biological therapy products, and sensitive diagnostic technologies. Among different types of biomedical materials, nonferrous metals and related materials (NMRMs) are important and attractive candidates. The updating of biomedical NMRMs and devices heavily relies on original research and application-oriented innovation. Here, we provide recent research findings and succinct insights into the developments in NMRMs for biomedical applications in China, including the use of titanium, magnesium, copper, zinc, cobalt, zirconium, hafnium, niobium, rhenium, tantalum, tungsten, silver, gold, platinum, palladium, their alloys and compounds, rare earths, high-entropy alloys, and liquid metals. Finally, the literature review concludes with several possible directions of NMRMs for new and future developments in biomedical engineering.

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摘要

生物医用材料是医学发展的物质基础, 有色金属及其他生物医用材料的科技创新推动了假体植入物、组织修复和再生、药物输送、治疗产品以及可穿戴诊断等方面不断取得新的突破, 为先进医疗技术的应用提供了重要支撑。原创性基础研究和应用创新研究是有色金属生物医用材料及医疗器械技术进步的源泉和动力。本文综述了近年来中国在有色金属生物医用材料研究领域取得的最新进展,涵盖了镁、铜、锌、钴、锆、铪、铌、铼、钽、钨、银、金、铂、钯、稀土、高熵合金和液态金属以及相关的合金、化合物、络合物在医学诊断、治疗、修复或替换病损组织与器官、增强特定功能等方面的应用。最后, 文章还展望了有色金属生物医用材料的未来发展和应用前景。

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Fig. 1

source: China Nonferrous Metal Industry Association)

Fig. 2

Reproduced with permission from Ref. [10]. Copyright 2010, The Author(s)

Fig. 3
Fig. 4

Reproduced from Ref. [36]. Copyright 2016, The Author(s)

Fig. 5

Reproduced with permission from Ref. [57]. Copyright 2016, Oxford University Press

Fig. 6

Reproduced with permission from Ref. [92]. Copyright 2020, Elsevier B.V

Fig. 7

Reproduced with permission from Ref. [121]. Copyright 2018, IEEE

Fig. 8

Reproduced with permission from Ref. [135]. Copyright 2020, The Nonferrous Metals Society of China and Springer-Verlag GmbH Germany, part of Springer Nature

Fig. 9

Reproduced from Ref. [140]. Copyright 2018, The Author(s)

Fig. 10

Reproduced with permission from Ref. [143]. Copyright 2021, American Chemical Society

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Acknowledgements

This study was financially supported by the Chinese Academy of Engineering (Nos. 2019-ZD-25-04, 2019-ZD-31-03, 2019-ZD-27-03, 2020-JJZD-1 and 2021-HYZD-6).

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  1. State Key Laboratory of Advanced Materials for Smart Sensing, GRINM Group Co., Ltd., Beijing, 100088, China

    Hai-Ling Tu & Hong-Bin Zhao

  2. China Academy of Space Technology, Beijing, 100094, China

    Yan-Yan Fan

  3. Key Laboratory of Microelectronics Devices & Integrated Technology, Institute of Microelectronics, CAS, Beijing, 100029, China

    Qing-Zhu Zhang

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Tu, HL., Zhao, HB., Fan, YY. et al. Recent developments in nonferrous metals and related materials for biomedical applications in China: a review. Rare Met. 41, 1410–1433 (2022). https://doi.org/10.1007/s12598-021-01905-y

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