Abstract
The review provides information on proteins with structural repeats, including their classification, characteristics, functions, and relevance in disease development. It explores methods for identifying structural repeats and specialized databases. The review also highlights the potential use of repeat proteins as drug design scaffolds and discusses their evolutionary mechanisms.
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Material preparation, data collection, and analysis were performed by Evgeniya I. Deryusheva, Andrey V. Machulin, and Oxana V. Galzitskaya. The first draft of the manuscript was written by Evgeniya I. Deryusheva, and all authors commented on subsequent versions of the manuscript. All authors read and approved the final manuscript.
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Deryusheva, E.I., Machulin, A.V. & Galzitskaya, O.V. Diversity and features of proteins with structural repeats. Biophys Rev 15, 1159–1169 (2023). https://doi.org/10.1007/s12551-023-01130-0
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DOI: https://doi.org/10.1007/s12551-023-01130-0