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A case of middle-aged male with multicentric solid pseudopapillary neoplasm of the pancreas

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Abstract

Solid pseudopapillary neoplasm (SPN) of the pancreas is a low-grade, malignant pancreatic tumor that occurs predominantly in young females. In this report, an extremely rare case of multicentric SPNs in a middle-aged male is discussed. A 55-year-old man was incidentally found to have a mass in the pancreatic body on abdominal ultrasonography during a medical checkup. Contrast-enhanced computed tomography (CT) revealed masses with 50-mm and 25-mm diameters with internal calcification in the pancreatic body and tail, respectively. These masses had a gradually increasing enhancement pattern though the center of the pancreatic body mass and the periphery of the pancreatic tail lesion were non-enhancing. Magnetic resonance imaging revealed a hyperintense signal in the mass of the pancreatic tail suggestive of hemorrhage on T1-weighted imaging. Positron emission tomography-CT revealed abnormal uptake of fluorodeoxyglucose in both lesions. Endoscopic ultrasound-guided fine needle aspiration was performed on both lesions, and tumor tissue with a solid proliferation of poorly pleomorphic small cells was observed. The tumor cells were positive for CD10 in the cytoplasm and β-catenin in the nucleus. The patient was diagnosed with SPNs and underwent a successful distal pancreatectomy.

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Acknowledgements

We would like to thank Editage (www.editage.com) for their English language editing.

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Authors and Affiliations

  1. Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan

    Kazuki Nakamura, Yasutaka Ishii, Masahiro Serikawa, Tomofumi Tsuboi, Tetsuro Hirano, Shinya Nakamura, Juri Ikemoto & Shiro Oka

  2. Department of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Kenichiro Uemura

  3. Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan

    Koji Arihiro

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  1. Kazuki Nakamura
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Correspondence to Yasutaka Ishii.

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Nakamura, K., Ishii, Y., Serikawa, M. et al. A case of middle-aged male with multicentric solid pseudopapillary neoplasm of the pancreas. Clin J Gastroenterol 16, 488–494 (2023). https://doi.org/10.1007/s12328-023-01785-y

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  • DOI: https://doi.org/10.1007/s12328-023-01785-y

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