Abstract
Multi-centric solid-pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor: only 4 cases are reported in the literature. The clinical and pathological features have not yet been fully clarified. We report 3 cases of multi-centric SPN and discuss their clinical presentations and histological and immunohistochemical features, comparing with solitary SPN. Among the total of 7 cases, 6 were female and 1 was male. Patients had nonspecific symptoms at presentation. Tumors were often large and well demarcated with cystic degeneration and clear margin between lumps. Histologically, characteristic pseudopapilla was formed with uniform cells surrounding the delicate blood vessels. Tumor cells were positive for vimentin, synaptophysin, progesterone receptor, and CD10 and demonstrated nuclear localization of β-catenin. The prognosis of patients was excellent after complete surgical resections. Multi-centric SPN shares similar clinical and pathological features to solitary SPN.
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References
Hruban RH, Pitman MB, Klimstra DS. Tumors of the pancreas. Atlas of tumor pathology: 4th series, fascicle. Washington, DC: ARP Press; 2007.
Chakhachiro ZI, Zaatari G. Solid-pseudopapillary neoplasm: a pancreatic enigma. Arch Pathol Lab Med. 2009;133:1989–93.
Orlando CA, Bowman RL, Loose JH. Multicentric papillary-cystic neoplasm of the pancreas. Arch Pathol Lab Med. 1991;115:958–60.
Kobayashi T, Kimura T, Takabayashi N, Sugimura H. Two synchronous solid and cystic tumors of the pancreas. J Gastroenterol. 1998;33:439–42.
Lloyd FP Jr, Kang J. Multifocal papillary-cystic neoplasm of the pancreas. J Natl Med Assoc. 2003;95:1204–7.
Hu S, Lin X, Song Q, Chen K. Multidetector CT of multicentric solid pseudopapillary tumor of the pancreas: a case report and review of the literature. Cancer Imaging. 2011;11:175–8.
Deshpande V, Oliva E, Young RH. Solid pseudopapillary neoplasm of the ovary: a report of 3 primary ovarian tumors resembling those of the pancreas. Am J Surg Pathol. 2010;34:1514–20.
Yang F, Fu DL, Jin C, Long J, Yu XJ, Xu J, et al. Clinical experiences of solid pseudopapillary tumors of the pancreas in China. Gastroenterol Hepatol. 2008;23:1847–51.
Klimstra DS. Nonductal neoplasms of the pancreas. Mod Pathol. 2007;20:S94–112.
Bergmann F, Andrulis M, Hartwig W, Penzel R, Gaida MM, Herpel E, et al. Discovered on gastrointestinal stromal tumor 1 (DOG1) is expressed in pancreatic centroacinar cells and in solid-pseudopapillary neoplasms–novel evidence for a histogenetic relationship. Hum Pathol. 2011;42:817–23.
Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, et al. Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol. 2002;160:1361–9.
Kosmahl M, Seada LS, Janig U, Harms D, Klöppel G. Solid-pseudopapillary tumor of the pancreas: its origin revisited. Virchows Arch. 2000;436:473–80.
Chen C, Jing W, Gulati P, Vargas H, French SW. Melanocytic differentiation in a solid pseudopapillary tumor of the pancreas. J Gastroenterol. 2004;39:579–83.
Liu X, Rauch TM, Siegal GP, Jhala N. Solid-pseudopapillary neoplasm of the pancreas: three cases with a literature review. Appl Immunohistochem Mol Morphol. 2006;14:445–53.
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Hai-xia Li and Ying Zhang contributed equally to this work.
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Li, Hx., Zhang, Y., Du, Zg. et al. Multi-centric solid-pseudopapillary neoplasm of the pancreas. Med Oncol 30, 330 (2013). https://doi.org/10.1007/s12032-012-0330-9
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DOI: https://doi.org/10.1007/s12032-012-0330-9